Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats

Farahnaz S. Joarder; Hussein Abou-Issa; Fredika M. Robertson; Michelle L. Parrett; Galal Alshafie; Randall E. Harris

doi:10.3892/or.4.6.1271

Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats

Farahnaz S. Joarder, Hussein Abou-Issa, Fredika M. Robertson, Michelle L. Parrett, Galal Alshafie, Randall E. Harris

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We examined effects of ibuprofen on the growth and development of DMBA- induced mammary cancers in mature female Sprague-Dawley rats. Ibuprofen was added to the standard diet at approximately 1,000 mg/kg rodent chow, resulting in an average daily dose of 25 mg per day per 0.25 kg rat. After five weeks of ibuprofen treatment, there was a 37% reduction in tumor volume compared to a 260% increase in the volume of tumors in untreated rats (p<0.001). These results suggest that ibuprofen may have potential in the chemoprevention and treatment of breast cancer.

Original language	English (US)
Pages (from-to)	1271-1273
Number of pages	3
Journal	Oncology Reports
Volume	4
Issue number	6
DOIs	https://doi.org/10.3892/or.4.6.1271
State	Published - 1997
Externally published	Yes

Keywords

Ibuprofen
Mammary cancer
NSAIDs
Sprague-Dawley rat

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats",

abstract = "We examined effects of ibuprofen on the growth and development of DMBA- induced mammary cancers in mature female Sprague-Dawley rats. Ibuprofen was added to the standard diet at approximately 1,000 mg/kg rodent chow, resulting in an average daily dose of 25 mg per day per 0.25 kg rat. After five weeks of ibuprofen treatment, there was a 37% reduction in tumor volume compared to a 260% increase in the volume of tumors in untreated rats (p<0.001). These results suggest that ibuprofen may have potential in the chemoprevention and treatment of breast cancer.",

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AU - Joarder, Farahnaz S.

AU - Abou-Issa, Hussein

AU - Robertson, Fredika M.

AU - Parrett, Michelle L.

AU - Alshafie, Galal

AU - Harris, Randall E.

PY - 1997

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AB - We examined effects of ibuprofen on the growth and development of DMBA- induced mammary cancers in mature female Sprague-Dawley rats. Ibuprofen was added to the standard diet at approximately 1,000 mg/kg rodent chow, resulting in an average daily dose of 25 mg per day per 0.25 kg rat. After five weeks of ibuprofen treatment, there was a 37% reduction in tumor volume compared to a 260% increase in the volume of tumors in untreated rats (p<0.001). These results suggest that ibuprofen may have potential in the chemoprevention and treatment of breast cancer.

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KW - Mammary cancer

KW - NSAIDs

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Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats

Abstract

Keywords

ASJC Scopus subject areas

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