Growth deficiency and malnutrition in Bloom syndrome

Charles Keller, Kelly R. Keller, Stephen B. Shew, Sharon E. Plon

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Objectives: To describe the growth and nutritional status of a pediatric population with Bloom syndrome. Study design: Longitudinal growth data from 148 patients in the Bloom's Syndrome Registry (85 male, 63 female) were compiled retrospectively from physician and parent records to develop graphed statistics of weight-for-age, height-for-age, fronto-occipital circumference- for-age, and weight-for-height for both sexes with comparisons with the normal population. Results: Term birth measurements confirm that the growth deficiency of Bloom syndrome has prenatal onset. Stunting persists throughout life, and an adolescent growth spurt is not apparent from the smoothed data. Growth continues by at least 1 cm/yr until age 21 years for both sexes. More than half of children with Bloom syndrome are significantly wasted until age 8 years, which is not related to early death or underlying malignancy. The mean body mass index for adults with Bloom syndrome after age 25 years is low normal (n = 22, mean = 20.2 kg/m2). Conclusions: Children with Bloom syndrome have significant growth retardation and wasting.

Original languageEnglish (US)
Pages (from-to)472-479
Number of pages8
JournalJournal of Pediatrics
Issue number4
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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