Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors

Claire E.H. Stewart, Peter Rotwein

Research output: Contribution to journalArticlepeer-review

708 Scopus citations


The insulin-like growth factors (IGFs), IGF-I aml IGF-II, comprise a conserved pair of secreted proteins with diverse effects on growth, development, and metabolism. Insulin-like growth factor action is initiated upon binding to cell-surface receptors and is modulated through interactions with secreted IGF binding proteins (IGFBPs). The last decade has seen an explosion of new information about the physiological roles of the IGFs. In this review, we critically examine this information from biochemical, cell biological, and molecular genetic perspectives. We discuss the structures and functions of the two IGF receptors, outline the actions of the six IGFBPs, and summarize and interpret recent studies highlighting essential roles for components of the IGF system in the growth and development of the embryo and fetus, in tissue differentiation, in cell survival and proliferation, and in cancer. These results are discussed in the context of new opportunities for understanding the mechanisms of IGF action in multiple biological processes.

Original languageEnglish (US)
Pages (from-to)1005-1026
Number of pages22
JournalPhysiological Reviews
Issue number4
StatePublished - Oct 1996
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Physiology (medical)


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