Growth Features of Choroidal Neovascular Membranes in Age-related Macular Degeneration

Michael L. Klein, Paul A. Jorizzo, Robert C. Watzke

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The authors studied 80 eyes of patients with choroidal neovascular membranes (CNVMs) associated with age-related macular degeneration between 1982 and 1988. In each case, fluorescein angiography was done on two occasions separated by an interval of 2 days to 11 weeks (average, 13 days) without intervening photocoagulation. Forty-three CNVMs (54%) grew toward the fovea during the interval between fluorescein angiograms, with growth rates ranging from 1 to 24 μm daily (average, 10 μm daily). The CNVM growth was related to the time interval between angiograms (P < 0.0001), but was not associated with morphologic features of the CNVM. These results reinforce the need for early detection and prompt evaluation of elderly patients with symptoms of CNVMs.

Original languageEnglish (US)
Pages (from-to)1416-1421
Number of pages6
Issue number9
StatePublished - 1989

ASJC Scopus subject areas

  • Ophthalmology


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