TY - JOUR
T1 - Hair-cell mechanotransduction and cochlear amplification
AU - LeMasurier, Meredith
AU - Gillespie, Peter G.
N1 - Funding Information:
We thank Rachel Dumont and Tianying Ren for comments on the manuscript, and David Corey and Joe Howard for discussions on the modeling. Work from the Gillespie lab is supported by the National Institute on Deafness and Other Communication Disorders grants DC002368, DC003279, DC004571, and DC005983.
PY - 2005/11/3
Y1 - 2005/11/3
N2 - In the inner ear, sensory hair cells not only detect but also amplify the softest sounds, allowing us to hear over an extraordinarily wide intensity range. This amplification is frequency specific, giving rise to exquisite frequency discrimination. Hair cells detect sounds with their mechanotransduction apparatus, which is only now being dissected molecularly. Signal detection is not the only role of this molecular network; amplification of low-amplitude signals by hair bundles seems to be universal in hair cells. "Fast adaptation," the rapid closure of transduction channels following a mechanical stimulus, appears to be intimately involved in bundle-based amplification.
AB - In the inner ear, sensory hair cells not only detect but also amplify the softest sounds, allowing us to hear over an extraordinarily wide intensity range. This amplification is frequency specific, giving rise to exquisite frequency discrimination. Hair cells detect sounds with their mechanotransduction apparatus, which is only now being dissected molecularly. Signal detection is not the only role of this molecular network; amplification of low-amplitude signals by hair bundles seems to be universal in hair cells. "Fast adaptation," the rapid closure of transduction channels following a mechanical stimulus, appears to be intimately involved in bundle-based amplification.
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U2 - 10.1016/j.neuron.2005.10.017
DO - 10.1016/j.neuron.2005.10.017
M3 - Review article
C2 - 16269359
AN - SCOPUS:27644507327
SN - 0896-6273
VL - 48
SP - 403
EP - 415
JO - Neuron
JF - Neuron
IS - 3
ER -