Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males

M. Michele Murburg; David Paly; Charles W. Wilkinson; Richard C. Veith; Kenneth L. Malas; Daniel M. Dorsa

doi:10.1016/0024-3205(86)90656-9

Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males

M. Michele Murburg, David Paly, Charles W. Wilkinson, Richard C. Veith, Kenneth L. Malas, Daniel M. Dorsa

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

To investigate possible central dopaminergic regulation of betaendorphin-like immunoreactivity (βE-LI) and adrenocorticotropin (ACTH) release in humans, we gave the dopamine antagonist haloperidol or placebo intravenously to twelve normal male subjects and measured βE-LI and cortisol for 120 minutes following injection. Haloperidol, but not placebo, produced significant increases in plasma βE-LI and cortisol. These findings suggest that central dopaminergic pathways such as the tuberohypophyseal system may participate in regulation of the secretion of βE and ACTH from the human pituitary.

Original language	English (US)
Pages (from-to)	373-381
Number of pages	9
Journal	Life Sciences
Volume	39
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(86)90656-9
State	Published - Jul 28 1986
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(86)90656-9

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title = "Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males",

abstract = "To investigate possible central dopaminergic regulation of betaendorphin-like immunoreactivity (βE-LI) and adrenocorticotropin (ACTH) release in humans, we gave the dopamine antagonist haloperidol or placebo intravenously to twelve normal male subjects and measured βE-LI and cortisol for 120 minutes following injection. Haloperidol, but not placebo, produced significant increases in plasma βE-LI and cortisol. These findings suggest that central dopaminergic pathways such as the tuberohypophyseal system may participate in regulation of the secretion of βE and ACTH from the human pituitary.",

author = "{Michele Murburg}, M. and David Paly and Wilkinson, {Charles W.} and Veith, {Richard C.} and Malas, {Kenneth L.} and Dorsa, {Daniel M.}",

note = "Funding Information: {"}Presented in part at the 15th Annual Meeting of the Society of Neuroscience, Dallas, Texas, 1985. This work was supported by the Research Service of the Veterans Administration, by a grant from the Alcohol and Drug Abuse Institute at the University of Washington, and by Clinical Neuroscience Training Grant Number 8-T32-N5-07144.",

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doi = "10.1016/0024-3205(86)90656-9",

language = "English (US)",

volume = "39",

pages = "373--381",

journal = "Life Sciences",

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T1 - Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males

AU - Michele Murburg, M.

AU - Paly, David

AU - Wilkinson, Charles W.

AU - Veith, Richard C.

AU - Malas, Kenneth L.

AU - Dorsa, Daniel M.

N1 - Funding Information: "Presented in part at the 15th Annual Meeting of the Society of Neuroscience, Dallas, Texas, 1985. This work was supported by the Research Service of the Veterans Administration, by a grant from the Alcohol and Drug Abuse Institute at the University of Washington, and by Clinical Neuroscience Training Grant Number 8-T32-N5-07144.

PY - 1986/7/28

Y1 - 1986/7/28

N2 - To investigate possible central dopaminergic regulation of betaendorphin-like immunoreactivity (βE-LI) and adrenocorticotropin (ACTH) release in humans, we gave the dopamine antagonist haloperidol or placebo intravenously to twelve normal male subjects and measured βE-LI and cortisol for 120 minutes following injection. Haloperidol, but not placebo, produced significant increases in plasma βE-LI and cortisol. These findings suggest that central dopaminergic pathways such as the tuberohypophyseal system may participate in regulation of the secretion of βE and ACTH from the human pituitary.

AB - To investigate possible central dopaminergic regulation of betaendorphin-like immunoreactivity (βE-LI) and adrenocorticotropin (ACTH) release in humans, we gave the dopamine antagonist haloperidol or placebo intravenously to twelve normal male subjects and measured βE-LI and cortisol for 120 minutes following injection. Haloperidol, but not placebo, produced significant increases in plasma βE-LI and cortisol. These findings suggest that central dopaminergic pathways such as the tuberohypophyseal system may participate in regulation of the secretion of βE and ACTH from the human pituitary.

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Haloperidol increases plasma beta endorphin-like immunoreactivity and cortisol in normal human males

Abstract

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