Hemorrhagic disease of the newborn despite vitamin K prophylaxis at birth

Veronica H. Flood, Faith C. Galderisi, Stefanie R. Lowas, Angela Kendrick, Lynn K. Boshkov

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Late hemorrhagic disease of the newborn (HDN) presents 0.5-6 months after birth with mucocutaneous and intracranial bleeding. We describe here two cases of late HDN in infants who received vitamin K. The first case is a previously healthy breastfed male who received one dose of oral vitamin K at birth and developed an intracranial hemorrhage 5 weeks later. He was treated with intravenous vitamin K and recombinant factor VIIa prior to emergent craniectomy. An unrelated infant presented at 5 months of age with diarrhea and easy bruising despite IM vitamin K at birth. These cases illustrate the morbidity associated with late HDN.

Original languageEnglish (US)
Pages (from-to)1075-1077
Number of pages3
JournalPediatric Blood and Cancer
Issue number5
StatePublished - May 2008


  • Bleeding disorders
  • Esp. in newborns
  • Intracranial hemorrhage
  • Vitamin K

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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