High concentrations of oxytocin in hypophysial portal plasma

Daniel M. Gibbs

doi:10.1210/endo-114-4-1216

High concentrations of oxytocin in hypophysial portal plasma

Daniel M. Gibbs

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

Hypophysial portal blood was collected from pentobarbital-anesthetized male rats, and the content of oxytocin (OT) was measured by RIA. The concentration of OT in portal plasma was 1.88 ± 0.48 ng/ml (SEM) and was at least 15 times higher than the concentration of OT in peripheral plasma samples from the same rats. Dilutions of portal plasma produced a displacement curve parallel to those of synthetic OT and posterior lobe extract. The data support a possible role for OT as a hypothalamic-releasing hormone.

Original language	English (US)
Pages (from-to)	1216-1218
Number of pages	3
Journal	Endocrinology
Volume	114
Issue number	4
DOIs	https://doi.org/10.1210/endo-114-4-1216
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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title = "High concentrations of oxytocin in hypophysial portal plasma",

abstract = "Hypophysial portal blood was collected from pentobarbital-anesthetized male rats, and the content of oxytocin (OT) was measured by RIA. The concentration of OT in portal plasma was 1.88 ± 0.48 ng/ml (SEM) and was at least 15 times higher than the concentration of OT in peripheral plasma samples from the same rats. Dilutions of portal plasma produced a displacement curve parallel to those of synthetic OT and posterior lobe extract. The data support a possible role for OT as a hypothalamic-releasing hormone.",

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AB - Hypophysial portal blood was collected from pentobarbital-anesthetized male rats, and the content of oxytocin (OT) was measured by RIA. The concentration of OT in portal plasma was 1.88 ± 0.48 ng/ml (SEM) and was at least 15 times higher than the concentration of OT in peripheral plasma samples from the same rats. Dilutions of portal plasma produced a displacement curve parallel to those of synthetic OT and posterior lobe extract. The data support a possible role for OT as a hypothalamic-releasing hormone.

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JO - Endocrinology

JF - Endocrinology

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High concentrations of oxytocin in hypophysial portal plasma

Abstract

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