High-Grade Glial Tumors Associated with ETV6-NTRK3 Gene Fusion: Imaging Appearance with Pathologic Correlate

J. P. Nickerson; M. Wood; M. Mossa-Basha; C. G. Filippi; D. Zarnow; J. Ji; J. A. Biegel; Y. Akkari; G. Ishak; R. Barajas

doi:10.3174/ng.2000068

High-Grade Glial Tumors Associated with ETV6-NTRK3 Gene Fusion: Imaging Appearance with Pathologic Correlate

J. P. Nickerson, M. Wood, M. Mossa-Basha, C. G. Filippi, D. Zarnow, J. Ji, J. A. Biegel, Y. Akkari, G. Ishak, R. Barajas

Research output: Contribution to journal › Article › peer-review

Abstract

Genetic analysis of high-grade glial tumors in children has revealed the presence of the ETV6-NTRK3 gene fusion in a small number of highly aggressive–appearing neoplasms. Identification of this gene fusion is important in that these patients may benefit from new, targeted therapies. Clinical presentation, imaging, and pathologic confirmation were obtained from 5 patients with confirmed ETV6-NTRK3 gene fusion. This case series may raise awareness of this entity and prompt genetic evaluation.

Original language	English (US)
Pages (from-to)	71-78
Number of pages	8
Journal	Neurographics
Volume	12
Issue number	2
DOIs	https://doi.org/10.3174/ng.2000068
State	Published - Apr 1 2022

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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abstract = "Genetic analysis of high-grade glial tumors in children has revealed the presence of the ETV6-NTRK3 gene fusion in a small number of highly aggressive–appearing neoplasms. Identification of this gene fusion is important in that these patients may benefit from new, targeted therapies. Clinical presentation, imaging, and pathologic confirmation were obtained from 5 patients with confirmed ETV6-NTRK3 gene fusion. This case series may raise awareness of this entity and prompt genetic evaluation.",

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AU - Nickerson, J. P.

AU - Wood, M.

AU - Mossa-Basha, M.

AU - Filippi, C. G.

AU - Zarnow, D.

AU - Ji, J.

AU - Biegel, J. A.

AU - Akkari, Y.

AU - Ishak, G.

AU - Barajas, R.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Genetic analysis of high-grade glial tumors in children has revealed the presence of the ETV6-NTRK3 gene fusion in a small number of highly aggressive–appearing neoplasms. Identification of this gene fusion is important in that these patients may benefit from new, targeted therapies. Clinical presentation, imaging, and pathologic confirmation were obtained from 5 patients with confirmed ETV6-NTRK3 gene fusion. This case series may raise awareness of this entity and prompt genetic evaluation.

AB - Genetic analysis of high-grade glial tumors in children has revealed the presence of the ETV6-NTRK3 gene fusion in a small number of highly aggressive–appearing neoplasms. Identification of this gene fusion is important in that these patients may benefit from new, targeted therapies. Clinical presentation, imaging, and pathologic confirmation were obtained from 5 patients with confirmed ETV6-NTRK3 gene fusion. This case series may raise awareness of this entity and prompt genetic evaluation.

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High-Grade Glial Tumors Associated with ETV6-NTRK3 Gene Fusion: Imaging Appearance with Pathologic Correlate

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