TY - JOUR
T1 - High plasma homocyst(e)ine levels in elderly Japanese patients are associated with increased cardiovascular disease risk independently from markers of coagulation activation and endothelial cell damage
AU - Kario, Kazuomi
AU - Barton Duell, P.
AU - Matsuo, Takefumi
AU - Sakata, Toshiyuki
AU - Kato, Hisao
AU - Shimada, Kazuyuki
AU - Miyata, Toshiyuki
N1 - Funding Information:
The authors thank Dr M. Rene Malinow for planning and discussion of this study, as well as measurements of plasma homocyst(e)ine and vitamins. This study was supported in part by grants in-aid (1992-2000) (KK) from the Foundation for the Development of the Community, Tochigi, Japan, Grants-in-Aid for Scientific Research from Ministry of Education (KK, TM), Science, Sports, and Culture of Japan, Special Coordination Funds for Promoting Science and Technology (Encouragement System of COE, TM), the Science and Technology Agency of Japan, Kato Memorial Bioscience Foundation, an Established Investigator Grant from the American Heart Association (PBD), and the National Institutes of Health, Bethesda, MD (RR00163) (MRM).
PY - 2001
Y1 - 2001
N2 - Elevated plasma homocyst(e)ine is a risk factor for cardiovascular disease (CVD) in many populations, but the relationship between homocyst(e)ine and CVD in Japanese subjects has been unclear. It has been hypothesized that the link between homocyst(e)ine and CVD may be mediated in part by activation of coagulation and endothelial cell injury in the elderly Japanese subjects. To further evaluate this hypothesis, the present cross-sectional study was designed to assess the relationships among plasma homocyst(e)ine concentrations, risk of CVD, and markers of coagulation (fibrinogen, FVII, F1 + 2, FVIIa and FXIIa) and endothelial cell damage (vWF and thrombomodulin) in 146 elderly Japanese subjects (79 healthy controls and 67 patients with CVD). The geometric mean (range) of plasma homocyst(e)ine concentrations was 10.2 (3.2-33) μmol/l in 79 Japanese healthy elderly subjects. As expected, healthy female and male elderly subjects had homocyst(e)ine levels that were 2.5 and 5.3 μmol/; higher, respectively, compared to healthy young control subjects (n = 62). Healthy young and elderly men had homocyst(e)ine levels that were 1.7 and 4.5 μmol/l higher, respectively, compared to values in women. This higher plasma homocyst(e)ine levels in the elderly subjects were negatively correlated with levels of folic acid, albumin and total cholesterol, but were not significantly related to markers of coagulation or endothelial cell-damage. The results of multiple logistic regression analyses suggested that high homocyst(e)ine levels were independently related to CVD risk. In addition, levels of FVIIa, and F1 + 2 were significantly higher in elderly Japanese patients with CVD compared to elderly subjects without CVD, but were unrelated to plasma homocyst(e)ine concentrations. In summary, elevated plasma concentrations of homocyst(e)ine, FVIIa, and F1 + 2 were associated with increased risk of CVD in elderly male and female Japanese subjects, but the association between homocyst(e)ine and CVD was unrelated to abnormalities in markers of coagulation and endothelial cell damage in this population.
AB - Elevated plasma homocyst(e)ine is a risk factor for cardiovascular disease (CVD) in many populations, but the relationship between homocyst(e)ine and CVD in Japanese subjects has been unclear. It has been hypothesized that the link between homocyst(e)ine and CVD may be mediated in part by activation of coagulation and endothelial cell injury in the elderly Japanese subjects. To further evaluate this hypothesis, the present cross-sectional study was designed to assess the relationships among plasma homocyst(e)ine concentrations, risk of CVD, and markers of coagulation (fibrinogen, FVII, F1 + 2, FVIIa and FXIIa) and endothelial cell damage (vWF and thrombomodulin) in 146 elderly Japanese subjects (79 healthy controls and 67 patients with CVD). The geometric mean (range) of plasma homocyst(e)ine concentrations was 10.2 (3.2-33) μmol/l in 79 Japanese healthy elderly subjects. As expected, healthy female and male elderly subjects had homocyst(e)ine levels that were 2.5 and 5.3 μmol/; higher, respectively, compared to healthy young control subjects (n = 62). Healthy young and elderly men had homocyst(e)ine levels that were 1.7 and 4.5 μmol/l higher, respectively, compared to values in women. This higher plasma homocyst(e)ine levels in the elderly subjects were negatively correlated with levels of folic acid, albumin and total cholesterol, but were not significantly related to markers of coagulation or endothelial cell-damage. The results of multiple logistic regression analyses suggested that high homocyst(e)ine levels were independently related to CVD risk. In addition, levels of FVIIa, and F1 + 2 were significantly higher in elderly Japanese patients with CVD compared to elderly subjects without CVD, but were unrelated to plasma homocyst(e)ine concentrations. In summary, elevated plasma concentrations of homocyst(e)ine, FVIIa, and F1 + 2 were associated with increased risk of CVD in elderly male and female Japanese subjects, but the association between homocyst(e)ine and CVD was unrelated to abnormalities in markers of coagulation and endothelial cell damage in this population.
KW - Cardiovascular disease
KW - Elderly
KW - Endothelial cell damage
KW - Factor VII
KW - Folate
KW - Homocyst(e)ine
KW - Japanese
KW - Malnutrition
KW - Myocardial infarction
KW - Stroke
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U2 - 10.1016/S0021-9150(00)00738-3
DO - 10.1016/S0021-9150(00)00738-3
M3 - Article
C2 - 11472745
AN - SCOPUS:0034905681
SN - 0021-9150
VL - 157
SP - 441
EP - 449
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -