Highly efficient method for C-5 halogenation of pyrimidine-based nucleosides in ionic liquids

Vineet Kumar; Jeremy Yap; Andrew Muroyama; Sanjay V. Malhotra

doi:10.1055/s-0029-1217042

Highly efficient method for C-5 halogenation of pyrimidine-based nucleosides in ionic liquids

Vineet Kumar, Jeremy Yap, Andrew Muroyama, Sanjay V. Malhotra

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A novel, highly efficient, convenient, and benign methodology for C-5 halogenation of pyrimidine-based nucleosides has been developed using N-halosuccinimides as halogenating reagents without using any catalyst in ionic liquid medium. The ionic liquids were successfully recovered and reused for all the reactions.

Original language	English (US)
Article number	M01709SS
Pages (from-to)	3957-3962
Number of pages	6
Journal	Synthesis
Issue number	23
DOIs	https://doi.org/10.1055/s-0029-1217042
State	Published - 2009
Externally published	Yes

Keywords

Halogenation
Ionic liquids
Nucleosides

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-0029-1217042

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title = "Highly efficient method for C-5 halogenation of pyrimidine-based nucleosides in ionic liquids",

abstract = "A novel, highly efficient, convenient, and benign methodology for C-5 halogenation of pyrimidine-based nucleosides has been developed using N-halosuccinimides as halogenating reagents without using any catalyst in ionic liquid medium. The ionic liquids were successfully recovered and reused for all the reactions.",

keywords = "Halogenation, Ionic liquids, Nucleosides",

author = "Vineet Kumar and Jeremy Yap and Andrew Muroyama and Malhotra, {Sanjay V.}",

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doi = "10.1055/s-0029-1217042",

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AU - Kumar, Vineet

AU - Yap, Jeremy

AU - Muroyama, Andrew

AU - Malhotra, Sanjay V.

PY - 2009

Y1 - 2009

N2 - A novel, highly efficient, convenient, and benign methodology for C-5 halogenation of pyrimidine-based nucleosides has been developed using N-halosuccinimides as halogenating reagents without using any catalyst in ionic liquid medium. The ionic liquids were successfully recovered and reused for all the reactions.

AB - A novel, highly efficient, convenient, and benign methodology for C-5 halogenation of pyrimidine-based nucleosides has been developed using N-halosuccinimides as halogenating reagents without using any catalyst in ionic liquid medium. The ionic liquids were successfully recovered and reused for all the reactions.

KW - Halogenation

KW - Ionic liquids

KW - Nucleosides

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DO - 10.1055/s-0029-1217042

M3 - Article

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JF - Synthesis

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M1 - M01709SS

ER -

Highly efficient method for C-5 halogenation of pyrimidine-based nucleosides in ionic liquids

Abstract

Keywords

ASJC Scopus subject areas

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