@article{45dd891e2f6c4fadb8d81983fdef2acb,
title = "Hirudin C-terminal fragments inhibit thrombin induced neutrophil chemotaxis",
abstract = "Since native hirudin blocks the thrombin induced chemotaxis response of neutrophils, we examined whether hirudin C-terminal peptides were also capable of this inhibition. The studies showed that thrombin induced human neutrophil chemotaxis was effectively blocked by the C-terminal hirudin peptide analogs, Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln (12-mer[54-65]) and Thr-Pro-Lys-Pro-Gln-Ser-His-Asn-Asp-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu -Gln (21-mer[45-65]). Furthermore, neither peptide had an effect on formyl-L-methionyl-L-leucyl-L-phenylalanine induced chemotaxis. The results suggest that binding of the hirudin C-terminal peptides block the thrombin chemotactic domain.",
author = "Rowand, \{J. K.\} and P. Marucha and Berliner, \{L. J.\}",
year = "1992",
doi = "10.1055/s-0038-1648433",
language = "English (US)",
volume = "67",
pages = "289--291",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Georg Thieme Verlag",
number = "3",
}