HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda

Mark J. Siedner; June Ho Kim; Ruth Sentongo Nakku; Linda Hemphill; Virginia A. Triant; Jessica E. Haberer; Jeffrey N. Martin; Yap Boum; Douglas S. Kwon; Alexander C. Tsai; Peter W. Hunt; Samson Okello; David R. Bangsberg

doi:10.1097/QAD.0000000000000992

HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda

Mark J. Siedner, June Ho Kim, Ruth Sentongo Nakku, Linda Hemphill, Virginia A. Triant, Jessica E. Haberer, Jeffrey N. Martin, Yap Boum, Douglas S. Kwon, Alexander C. Tsai, Peter W. Hunt, Samson Okello, David R. Bangsberg

School Of Public Health

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

HIV infection is associated with arterial stiffness, but no studies have assessed this relationship in sub-Saharan Africa. We enrolled 205 participants over 40 years old in Uganda: 105 on antiretroviral therapy for a median of 7 years, and a random sample of 100 age and sex-matched HIV-uninfected controls from the clinic catchment area. The prevalence of arterial stiffness (ankle brachial index >1.2) was 33%, 18%, 19% and 2% in HIV+ men, HIV-men, HIV+ women, and HIV-women. In multivariable models adjusted for cardiovascular risk factors, HIV+ individuals had over double the prevalence of arterial stiffness (adjusted prevalence ratio 2.86, 95% confidence interval 1.41-5.79, P=0.003).

Original language	English (US)
Pages (from-to)	667-670
Number of pages	4
Journal	AIDS
Volume	30
Issue number	4
DOIs	https://doi.org/10.1097/QAD.0000000000000992
State	Published - Feb 20 2016

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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title = "HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda",

abstract = "HIV infection is associated with arterial stiffness, but no studies have assessed this relationship in sub-Saharan Africa. We enrolled 205 participants over 40 years old in Uganda: 105 on antiretroviral therapy for a median of 7 years, and a random sample of 100 age and sex-matched HIV-uninfected controls from the clinic catchment area. The prevalence of arterial stiffness (ankle brachial index >1.2) was 33%, 18%, 19% and 2% in HIV+ men, HIV-men, HIV+ women, and HIV-women. In multivariable models adjusted for cardiovascular risk factors, HIV+ individuals had over double the prevalence of arterial stiffness (adjusted prevalence ratio 2.86, 95% confidence interval 1.41-5.79, P=0.003).",

author = "Siedner, {Mark J.} and Kim, {June Ho} and Nakku, {Ruth Sentongo} and Linda Hemphill and Triant, {Virginia A.} and Haberer, {Jessica E.} and Martin, {Jeffrey N.} and Yap Boum and Kwon, {Douglas S.} and Tsai, {Alexander C.} and Hunt, {Peter W.} and Samson Okello and Bangsberg, {David R.}",

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T1 - HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda

AU - Siedner, Mark J.

AU - Kim, June Ho

AU - Nakku, Ruth Sentongo

AU - Hemphill, Linda

AU - Triant, Virginia A.

AU - Haberer, Jessica E.

AU - Martin, Jeffrey N.

AU - Boum, Yap

AU - Kwon, Douglas S.

AU - Tsai, Alexander C.

AU - Hunt, Peter W.

AU - Okello, Samson

AU - Bangsberg, David R.

PY - 2016/2/20

Y1 - 2016/2/20

N2 - HIV infection is associated with arterial stiffness, but no studies have assessed this relationship in sub-Saharan Africa. We enrolled 205 participants over 40 years old in Uganda: 105 on antiretroviral therapy for a median of 7 years, and a random sample of 100 age and sex-matched HIV-uninfected controls from the clinic catchment area. The prevalence of arterial stiffness (ankle brachial index >1.2) was 33%, 18%, 19% and 2% in HIV+ men, HIV-men, HIV+ women, and HIV-women. In multivariable models adjusted for cardiovascular risk factors, HIV+ individuals had over double the prevalence of arterial stiffness (adjusted prevalence ratio 2.86, 95% confidence interval 1.41-5.79, P=0.003).

AB - HIV infection is associated with arterial stiffness, but no studies have assessed this relationship in sub-Saharan Africa. We enrolled 205 participants over 40 years old in Uganda: 105 on antiretroviral therapy for a median of 7 years, and a random sample of 100 age and sex-matched HIV-uninfected controls from the clinic catchment area. The prevalence of arterial stiffness (ankle brachial index >1.2) was 33%, 18%, 19% and 2% in HIV+ men, HIV-men, HIV+ women, and HIV-women. In multivariable models adjusted for cardiovascular risk factors, HIV+ individuals had over double the prevalence of arterial stiffness (adjusted prevalence ratio 2.86, 95% confidence interval 1.41-5.79, P=0.003).

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HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda

Abstract

ASJC Scopus subject areas

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