Hodgkin Lymphoma and the Microenvironment

M. J. Cascio, Y. Natkunam

Research output: Chapter in Book/Report/Conference proceedingChapter


Hodgkin lymphoma (HL) is a maLignant neoplasm derived from germinal center B-cells. The histopathologic findings in HL are unique in that the neoplastic cells are relatively few in number and can be obscured by large numbers of nonneoplastic cells, including lymphocytes, macrophages, plasma cells, eosinophils, and fibroblasts. The microenvironment encompasses all of the inflammatory cells, fibroblasts, blood vessels, and cytokines found within the vicinity of the neoplastic cell population. The relationship between the tumor cell population and the microenvironment is critical for tumor growth and survival. The pecuLiar histopathologic findings of HL have lead investigators to study the role of the microenvironment with respect to disease pathogenesis and cLinical outcomes. Herein, we review the role of the microenvironment of HL and its relationship to disease pathogenesis through the modulation of host cell response. We conclude with a brief description of new therapeutics targeting molecules in the microenvironment.

Original languageEnglish (US)
Title of host publicationPathobiology of Human Disease
Subtitle of host publicationA Dynamic Encyclopedia of Disease Mechanisms
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780123864567
ISBN (Print)9780123864574
StatePublished - Jan 1 2014
Externally publishedYes


  • Epstein-Barr virus
  • Galectin-3
  • Hodgkin lymphoma
  • Microenvironment

ASJC Scopus subject areas

  • Medicine(all)


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