Background:Versican interacts with hyaluronan (HA) via its G1 domain and with fibrillin microfibrils via its G3 domain. However, the roles of versican G1 domain-containing fragments (VG1Fs) in the HA-versican-microfibril macrocomplex are not clear. Results:VG1Fs interact homotypically and are recaptured by versican-containing fibrillin microfibrils. Conclusion:Homotypical interactions of VG1Fs enhance HA recruitment to microfibrils. Significance:VG1Fs stabilize HA-versican-microfibril macrocomplexes.
|Original language||English (US)|
|Number of pages||12|
|Journal||Journal of Biological Chemistry|
|State||Published - Oct 4 2013|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology