Abstract
Background:Versican interacts with hyaluronan (HA) via its G1 domain and with fibrillin microfibrils via its G3 domain. However, the roles of versican G1 domain-containing fragments (VG1Fs) in the HA-versican-microfibril macrocomplex are not clear. Results:VG1Fs interact homotypically and are recaptured by versican-containing fibrillin microfibrils. Conclusion:Homotypical interactions of VG1Fs enhance HA recruitment to microfibrils. Significance:VG1Fs stabilize HA-versican-microfibril macrocomplexes.
Original language | English (US) |
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Pages (from-to) | 29170-29181 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 40 |
DOIs | |
State | Published - Oct 4 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology