Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

A. Ullrich; L. Coussens; J. S. Hayflick; T. J. Dull; A. Gray; A. W. Tam; J. Lee; Y. Yarden; T. A. Libermann; J. Schlessinger; J. Downward; E. L.V. Mayes; N. Whittle; M. D. Waterfield; P. H. Seeburg

doi:10.1038/309418a0

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

A. Ullrich, L. Coussens, J. S. Hayflick, T. J. Dull, A. Gray, A. W. Tam, J. Lee, Y. Yarden, T. A. Libermann, J. Schlessinger, J. Downward, E. L.V. Mayes, N. Whittle, M. D. Waterfield, P. H. Seeburg

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Abstract

The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. A single transmembrane region of 23 amino acids separates the extracellular EGF binding and cytoplasmic domains. The receptor gene is amplified and apparently rearranged in A431 cells, generating a truncated 2.8-kilobase mRNA which encodes only the extracellular EGF binding domain.

Original language	English (US)
Pages (from-to)	418-425
Number of pages	8
Journal	Nature
Volume	309
Issue number	5967
DOIs	https://doi.org/10.1038/309418a0
State	Published - 1984
Externally published	Yes

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Ullrich, A., Coussens, L., Hayflick, J. S., Dull, T. J., Gray, A., Tam, A. W., Lee, J., Yarden, Y., Libermann, T. A., Schlessinger, J., Downward, J., Mayes, E. L. V., Whittle, N., Waterfield, M. D., & Seeburg, P. H. (1984). Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature, 309(5967), 418-425. https://doi.org/10.1038/309418a0

Ullrich, A, Coussens, L, Hayflick, JS, Dull, TJ, Gray, A, Tam, AW, Lee, J, Yarden, Y, Libermann, TA, Schlessinger, J, Downward, J, Mayes, ELV, Whittle, N, Waterfield, MD & Seeburg, PH 1984, 'Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells', Nature, vol. 309, no. 5967, pp. 418-425. https://doi.org/10.1038/309418a0

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abstract = "The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. A single transmembrane region of 23 amino acids separates the extracellular EGF binding and cytoplasmic domains. The receptor gene is amplified and apparently rearranged in A431 cells, generating a truncated 2.8-kilobase mRNA which encodes only the extracellular EGF binding domain.",

author = "A. Ullrich and L. Coussens and Hayflick, {J. S.} and Dull, {T. J.} and A. Gray and Tam, {A. W.} and J. Lee and Y. Yarden and Libermann, {T. A.} and J. Schlessinger and J. Downward and Mayes, {E. L.V.} and N. Whittle and Waterfield, {M. D.} and Seeburg, {P. H.}",

year = "1984",

doi = "10.1038/309418a0",

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volume = "309",

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T1 - Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

AU - Ullrich, A.

AU - Coussens, L.

AU - Hayflick, J. S.

AU - Dull, T. J.

AU - Gray, A.

AU - Tam, A. W.

AU - Lee, J.

AU - Yarden, Y.

AU - Libermann, T. A.

AU - Schlessinger, J.

AU - Downward, J.

AU - Mayes, E. L.V.

AU - Whittle, N.

AU - Waterfield, M. D.

AU - Seeburg, P. H.

PY - 1984

Y1 - 1984

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AB - The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted ν-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. A single transmembrane region of 23 amino acids separates the extracellular EGF binding and cytoplasmic domains. The receptor gene is amplified and apparently rearranged in A431 cells, generating a truncated 2.8-kilobase mRNA which encodes only the extracellular EGF binding domain.

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Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

Abstract

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