TY - JOUR
T1 - Human transfer factor activity in the guinea pig
T2 - Absence of antigen specificity
AU - Vandenbark, Arthur A.
AU - Burger, Denis R.
AU - Vetto, R. Mark
PY - 1977/7
Y1 - 1977/7
N2 - Human transfer factor of known antigen specificity was used to induce skin-test reactivity in strain 13 guinea pigs. This reactivity is reproducible, is dependent upon preexposure of the animal to subsensitizing doses of antigen, persists for at least 14 weeks, and is reflected in some cases by antigen-induced lymphocyte transformation. The skin test response in guinea pigs does not reflect the antigen reactivities of the human TF donor; this suggests that in guinea pigs the TF may augment a low level of sensitization produced during the priming step.
AB - Human transfer factor of known antigen specificity was used to induce skin-test reactivity in strain 13 guinea pigs. This reactivity is reproducible, is dependent upon preexposure of the animal to subsensitizing doses of antigen, persists for at least 14 weeks, and is reflected in some cases by antigen-induced lymphocyte transformation. The skin test response in guinea pigs does not reflect the antigen reactivities of the human TF donor; this suggests that in guinea pigs the TF may augment a low level of sensitization produced during the priming step.
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U2 - 10.1016/0090-1229(77)90086-1
DO - 10.1016/0090-1229(77)90086-1
M3 - Article
C2 - 69512
AN - SCOPUS:0017377811
SN - 0090-1229
VL - 8
SP - 7
EP - 16
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 1
ER -