TY - JOUR
T1 - Hypertension, systemic inflammation and body weight in relation to lung function impairmentan epidemiological study
AU - Margretardottir, Olof Birna
AU - Thorleifsson, Sigurdur James
AU - Gudmundsson, Gunnar
AU - Olafsson, Isleifur
AU - Benediktsdottir, Bryndis
AU - Janson, Christer
AU - Buist, A. Sonia
AU - Gislason, Thorarinn
N1 - Funding Information:
This study was funded by Landspitali University Science Fund, Astra Zeneca in Iceland and GlaxoSmithKline in Iceland.
Funding Information:
Keywords: Airflow obstruction, hypertension, obesity, systemic inflammation, cytokines Grants: This study was funded by Landspitali University Science Fund, Astra Zeneca in Iceland and GlaxoSmithKline in Iceland. Correspondence to: Thorarinn Gislason Department of Respiratory Medicine and Sleep (E7) Landspitali University Hospital 108 Reykjavík, Iceland. phone: +354-5431000; fax: +354-5436568 email: thorarig@landspitali.is
PY - 2009
Y1 - 2009
N2 - Recent reports on the simultaneous occurrence of systemic inflammation and airflow obstruction are usually based on a highly selective patient population, but their importance warrants further evaluation in the general population. The objectives were to study the interrelationship between airflow obstruction, smoking, hypertension, obesity and CRP as a marker of systemic inflammation in a randomly selected sample of the general Icelandic population (n 939). This study comprised 758 randomly selected men and women 40 years and older living in Reykjavik, Iceland, and who were participating in the Burden of Obstructive Lung Disease (BOLD) study (81 response rate). In addition to the BOLD protocol, which included post-bronchodilator spirometry, they answered questions about general health and medication. Serum samples were taken for measurement of C-reactive protein (CRP). In the sample245 individuals (33) reported having hypertension. Subjects with hypertension were older, had a higher BMI and higher CRP levels. Subjects with hypertension had lower values of FEV1 than predicted (89.9 ± 18.5 vs. 94.5 ± 14.4) (p < 0.001) and FVC (92.2 ± 15.1 vs. 95.3 ± 12.3) (p 0.002). These differences remained significant after adjusting for age, BMI, CRP and smoking. Hypertension and CRP levels above the median were both independently and additively associated with lower FEV1 and FVC. In addition a lower FVC was also associated with a higher BMI (> 30 mg/m2). Use of betablocking antihypertensives was not related to lung function. Hypertension, BMI and systemic inflammation affect lung function independently of each other. All three variables have a negative effect on FVC, while hypertension and high CRP were independently associated with impaired FEV1.
AB - Recent reports on the simultaneous occurrence of systemic inflammation and airflow obstruction are usually based on a highly selective patient population, but their importance warrants further evaluation in the general population. The objectives were to study the interrelationship between airflow obstruction, smoking, hypertension, obesity and CRP as a marker of systemic inflammation in a randomly selected sample of the general Icelandic population (n 939). This study comprised 758 randomly selected men and women 40 years and older living in Reykjavik, Iceland, and who were participating in the Burden of Obstructive Lung Disease (BOLD) study (81 response rate). In addition to the BOLD protocol, which included post-bronchodilator spirometry, they answered questions about general health and medication. Serum samples were taken for measurement of C-reactive protein (CRP). In the sample245 individuals (33) reported having hypertension. Subjects with hypertension were older, had a higher BMI and higher CRP levels. Subjects with hypertension had lower values of FEV1 than predicted (89.9 ± 18.5 vs. 94.5 ± 14.4) (p < 0.001) and FVC (92.2 ± 15.1 vs. 95.3 ± 12.3) (p 0.002). These differences remained significant after adjusting for age, BMI, CRP and smoking. Hypertension and CRP levels above the median were both independently and additively associated with lower FEV1 and FVC. In addition a lower FVC was also associated with a higher BMI (> 30 mg/m2). Use of betablocking antihypertensives was not related to lung function. Hypertension, BMI and systemic inflammation affect lung function independently of each other. All three variables have a negative effect on FVC, while hypertension and high CRP were independently associated with impaired FEV1.
KW - Airflow obstruction
KW - Cytokines
KW - Hypertension
KW - Obesity
KW - Systemic inflammation
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U2 - 10.1080/15412550903049157
DO - 10.1080/15412550903049157
M3 - Article
C2 - 19811383
AN - SCOPUS:70350433688
SN - 1541-2555
VL - 6
SP - 250
EP - 255
JO - COPD: Journal of Chronic Obstructive Pulmonary Disease
JF - COPD: Journal of Chronic Obstructive Pulmonary Disease
IS - 4
ER -