Hypothalamic inflammation and food intake regulation during chronic illness

J. T. Dwarkasing, D. L. Marks, R. F. Witkamp, K. Van Norren

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Anorexia is a common symptom in chronic illness. It contributes to malnutrition and strongly affects survival and quality of life. A common denominator of many chronic diseases is an elevated inflammatory status, which is considered to play a pivotal role in the failure of food-intake regulating systems in the hypothalamus. In this review, we summarize findings on the role of hypothalamic inflammation on food intake regulation involving hypothalamic neuropeptide Y (NPY) and pro-opiomelanocortin (POMC). Furthermore, we outline the role of serotonin in the inability of these peptide based food-intake regulating systems to respond and adapt to changes in energy metabolism during chronic disease.

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
StatePublished - Mar 1 2016


  • Anorexia
  • Hypothalamus
  • Inflammation
  • Melanocortins
  • NPY
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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