Iatrogenic arterial spasm relieved by intraarterial mannitol infusion

David Fortin, Eva Osztie, Edward A. Neuwelt

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Catheter placement for blood brain-barrier disruption and enhanced chemotherapy delivery can sometimes trigger arterial spasm of moderate-to- severe degree. A slow infusion of a small quantity of intraarterially administered mannitol (10 mL of 25% mannitol) was evaluated as a means to obtain a rapid resolution of catheter placement-induced spasm. We prospectively report 12 consecutive cases of blood brain-barrier disruption among patients who developed catheter placement-induced spasm that was treated by this means without side effects, resulting in rapid resolution of spasm.

Original languageEnglish (US)
Pages (from-to)968-970
Number of pages3
JournalAmerican Journal of Neuroradiology
Issue number5
StatePublished - 2000

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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