Identification and characteristic of LDL-subfractions in human plasma.

Y. D. Kholodova, W. S. Harris

Research output: Contribution to journalArticlepeer-review


Density gradient ultracentrifugation and high resolution polyacrylamide gel electrophoresis (Lipoprint LDL-system) were used to examine the discrete LDL subfraction patterns in normal and hyperlipidemic patients. Two new programs for LDL and VLDL subfractions were elaborated and a new method of evaluation for cholesterol content in LDL-subfractions, based on area distribution ratio of densitograms without density gradient ultracentrifugation, was created. The predominance of cholesterol and triglycerides in dense LDL3-subclass (d-1,048-1,063 g/ml) under hypercholesterolemia and hypertriglyceridemia was found. Lipoprint LDL-electrophoresis method was developed for the characteristic of lipemic state of organism and detection and quantitation of plasma LDL subfractions.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalUkrainskii biokhimicheskii zhurnal
Issue number6
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry


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