Abstract
Recent electrophysiological experiments have shown that retinal pigment epithelium (RPE) cells begin to produce neuronal-type voltage-dependent sodium currents when placed in dissociated cell culture. In this study, the sodium channel types induced in cultured rat RPE cells were identified. Sodium channel mRNAs encoding two distinct alpha subunits were detected in the cultured RPE cells, brain type II/IIA, and a novel rat mRNA which we have termed RET1. These two sodium channel types may correspond to the TTX-sensitive and TTX-insensitive components of sodium current reported previously in cultured rat RPE cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1001-1005 |
| Number of pages | 5 |
| Journal | Visual neuroscience |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
Funding
This research was supported by NIH Grants NS22518 (G. Mandel) and EYO3821 (G. Matthews). We thank Stephanie Burke for excellent technical assistance.
| Funders | Funder number |
|---|---|
| Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health | EYO3821 |
| National Institute of Neurological Disorders and Stroke | R01NS022518 |
Keywords
- Molecular biology
- Retina
- Retinal pigment epithelium
- Sodium channel
ASJC Scopus subject areas
- Physiology
- Sensory Systems
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