Identification of variant-specific functions of PIK3CA by rapid phenotyping of rare mutations

Keyphrases

• PIK3CA 100%
• Rare mutation 100%
• Rapid Phenotyping 100%
• Phosphatidylinositol 4-kinase (PI4K) 40%
• Cell Growth 20%
• In Cancer 20%
• Catalytic Subunit 20%
• Mitogen-activated Protein Kinase 20%
• Cancer Treatment 20%
• Kinase Signaling 20%
• Cell Transformation 20%
• Specific mutation 20%
• MEK1 20%
• Gene Variants 20%
• Transformation Assay 20%
• Tumor Progression 20%
• Oncogenic Activity 20%
• Long Tail 20%
• Proteomic Profiling 20%
• Functional Relevance 20%
• Barcoding 20%
• Alpha Subunit 20%
• Mutation Frequency 20%
• Growth Assay 20%
• Sensitivity Test 20%
• PIK3CA mutation 20%
• Cancer Genome 20%
• Breast Cancer Population 20%
• Passenger mutation 20%
• Driver mutations 20%
• Uncharacterized Genes 20%
• Driver Genes 20%
• Chemotherapy Sensitivity 20%
• Tumor Sequencing 20%
• Large-scale Sequencing 20%
• Sequencing Effort 20%
• Orthogonal Screening 20%
• Infrequent mutations 20%
• Cancer Driver Genes 20%
• High-throughput Engineering 20%

Biochemistry, Genetics and Molecular Biology

• Phosphatidylinositol-4,5-bisphosphate 3-Kinase 100%
• Cell Growth 50%
• Enzyme Active Site 50%
• Wild Type 50%
• Mitogen-Activated Protein Kinase 50%
• Cell Transformation 50%
• Carcinogenesis 50%
• Tumor Progression 50%
• Mutation Rate 50%
• Alpha Chain 50%
• Proteomics 50%
• Oncogenic activity 50%