Imaging of iris lesions with high-speed optical coherence tomography

Sophie J. Bakri, Arun D. Singh, Careen Y. Lowder, Maria Regina Chalita, Yan Li, Joseph A. Izatt, Andrew M. Rollins, David Huang

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


■ BACKGROUND AND OBJECTIVES: To image and measure iris tumors with optical coherence tomography (OCT). ■ PATIENTS AND METHODS: High-speed (2,000-4,000 axial-scan/sec and 4-16 frames/sec) 1.3-micron wavelength anterior segment OCT prototypes were used to image 6 eyes of 6 patients with a variety of iris lesions, including focal iris nevus, diffuse iris nevus, amelanotic iris nevus, iris melanocytosis, and iris melanoma. OCT images were compared with slit-lamp photography and ultrasound biomicroscopy. ■ RESULTS: OCT at 1.3-micron wavelength could penetrate the full thickness of the iris lesions and allow three-dimensional measurement of lesion size. Internal reflectivity is correlated with pigmentation. OCT is a convenient non-contact method that provides imaging of the clinically important angle structures (scleral spur and angle recess). ■ CONCLUSIONS: OCT is a new imaging modality that complements slit-lamp photography and ultrasound biomicroscopy for serial evaluation of iris lesions.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalOphthalmic Surgery Lasers and Imaging
Issue number1
StatePublished - 2007

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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