Immobilization of Actively Thromboresistant Assemblies on Sterile Blood-Contacting Surfaces

Zheng Qu, Venkat Krishnamurthy, Carolyn A. Haller, Brent M. Dorr, Ulla M. Marzec, Sawan Hurst, Monica T. Hinds, Stephen R. Hanson, David R. Liu, Elliot L. Chaikof

Research output: Contribution to journalLetterpeer-review

27 Scopus citations


Rapid one-step modification of thrombomodulin with alkylamine derivatives such as azide, biotin, and PEG is achieved using an evolved sortase (eSrtA) mutant. The feasibility of a point-of-care scheme is demonstrated herein to site-specifically immobilize azido-thrombomodulin on sterilized commercial ePTFE vascular grafts, which exhibit superior thromboresistance compared with commercial heparin-coated grafts in a primate model of acute graft thrombosis.

Original languageEnglish (US)
Pages (from-to)30-35
Number of pages6
JournalAdvanced Healthcare Materials
Issue number1
StatePublished - Jan 2014


  • Antifouling
  • Biocompatible materials
  • Biomedical applications
  • Thrombomodulin
  • Thrombosis

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


Dive into the research topics of 'Immobilization of Actively Thromboresistant Assemblies on Sterile Blood-Contacting Surfaces'. Together they form a unique fingerprint.

Cite this