Immune complex nephropathy in mixed connective tissue disease

Robert M. Bennett; Benjamin H. Spargo

doi:10.1016/0002-9343(77)90198-X

Immune complex nephropathy in mixed connective tissue disease

Robert M. Bennett
, Benjamin H. Spargo

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Initial reports on the clinical spectrum of mixed connective tissue disease (MCTD) indicated that renal involvement was uncommon. Four of 20 patients with MCTD underwent renal biopsy and all showed evidence of immune complex trapping with a membranous glomerulonephritis in three patients. Clinically evident renal disease was absent in two patients. These findings suggest that renal involvement in MCTD may be more prevalent than previously indicated.

Original language	English (US)
Pages (from-to)	534-541
Number of pages	8
Journal	The American Journal of Medicine
Volume	63
Issue number	4
DOIs	https://doi.org/10.1016/0002-9343(77)90198-X
State	Published - Oct 1977
Externally published	Yes

Funding

From the Departments of Medicine and Pathology, University of Chicago, and the Pritzker School of Medicine, Chicago, Illinois. This work was supported by a grant from the Illinois Chapter of the Arthritis Foundation and from a Center grant from the National Arthritis Foundation. Requests for reprints should be addressed to Dr. R. M. Bennett, Division of Immunology, Allergy and Rheumatology, University of Oregon Health Sciences Center, Portland, Oregon 97201. Manuscript accepted December 17, 1976. * Recipient of a Public Health Research Career Award K6-HL-44 18.

Funders
Arthritis National Research Foundation
Arthritis Foundation

ASJC Scopus subject areas

General Medicine

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10.1016/0002-9343(77)90198-X

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title = "Immune complex nephropathy in mixed connective tissue disease",

abstract = "Initial reports on the clinical spectrum of mixed connective tissue disease (MCTD) indicated that renal involvement was uncommon. Four of 20 patients with MCTD underwent renal biopsy and all showed evidence of immune complex trapping with a membranous glomerulonephritis in three patients. Clinically evident renal disease was absent in two patients. These findings suggest that renal involvement in MCTD may be more prevalent than previously indicated.",

author = "Bennett, \{Robert M.\} and Spargo, \{Benjamin H.\}",

note = "Funding Information: From the Departments of Medicine and Pathology, University of Chicago, and the Pritzker School of Medicine, Chicago, Illinois. This work was supported by a grant from the Illinois Chapter of the Arthritis Foundation and from a Center grant from the National Arthritis Foundation. Requests for reprints should be addressed to Dr. R. M. Bennett, Division of Immunology, Allergy and Rheumatology, University of Oregon Health Sciences Center, Portland, Oregon 97201. Manuscript accepted December 17, 1976. * Recipient of a Public Health Research Career Award K6-HL-44 18.",

year = "1977",

month = oct,

doi = "10.1016/0002-9343(77)90198-X",

language = "English (US)",

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pages = "534--541",

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T1 - Immune complex nephropathy in mixed connective tissue disease

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AU - Spargo, Benjamin H.

N1 - Funding Information: From the Departments of Medicine and Pathology, University of Chicago, and the Pritzker School of Medicine, Chicago, Illinois. This work was supported by a grant from the Illinois Chapter of the Arthritis Foundation and from a Center grant from the National Arthritis Foundation. Requests for reprints should be addressed to Dr. R. M. Bennett, Division of Immunology, Allergy and Rheumatology, University of Oregon Health Sciences Center, Portland, Oregon 97201. Manuscript accepted December 17, 1976. * Recipient of a Public Health Research Career Award K6-HL-44 18.

PY - 1977/10

Y1 - 1977/10

N2 - Initial reports on the clinical spectrum of mixed connective tissue disease (MCTD) indicated that renal involvement was uncommon. Four of 20 patients with MCTD underwent renal biopsy and all showed evidence of immune complex trapping with a membranous glomerulonephritis in three patients. Clinically evident renal disease was absent in two patients. These findings suggest that renal involvement in MCTD may be more prevalent than previously indicated.

AB - Initial reports on the clinical spectrum of mixed connective tissue disease (MCTD) indicated that renal involvement was uncommon. Four of 20 patients with MCTD underwent renal biopsy and all showed evidence of immune complex trapping with a membranous glomerulonephritis in three patients. Clinically evident renal disease was absent in two patients. These findings suggest that renal involvement in MCTD may be more prevalent than previously indicated.

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ER -

Immune complex nephropathy in mixed connective tissue disease

Abstract

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