IMMUNE RESPONSE OF LYMPHOCYTES FROM PATIENTS WITH MULTIPLE SCLEROSIS TO PHYTOHEMAGGLUTININ, BASIC PROTEIN OF MYELIN AND MEASLES ANTIGENS

H. Offner; T. Ammitzboll; J. Clausen; T. Fog; K. Hyllested; E. Einstein

doi:10.1111/j.1600-0404.1974.tb02786.x

IMMUNE RESPONSE OF LYMPHOCYTES FROM PATIENTS WITH MULTIPLE SCLEROSIS TO PHYTOHEMAGGLUTININ, BASIC PROTEIN OF MYELIN AND MEASLES ANTIGENS

H. Offner, T. Ammitzboll, J. Clausen, T. Fog, K. Hyllested, E. Einstein

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Abstract

The effect of phytohemagglutinin (PHA), basic protein (BP) and various measles antigens was studied in vitro on “whole blood cultures” from MS patients and controls. Lymphocytes from both MS patients and controls did not transform in vitro in the presence of basic protein and measles antigens. Quantitative studies with a liquid scintillation technique after incorporation of tritiated thymidine showed impaired lymphocyte transformation with PHA in 9 out of 26 MS patients. There was a correlation between duration of the disease and transformation of lymphocytes from MS patients.

Original language	English (US)
Pages (from-to)	373-381
Number of pages	9
Journal	Acta Neurologica Scandinavica
Volume	50
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0404.1974.tb02786.x
State	Published - Jun 1974
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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abstract = "The effect of phytohemagglutinin (PHA), basic protein (BP) and various measles antigens was studied in vitro on “whole blood cultures” from MS patients and controls. Lymphocytes from both MS patients and controls did not transform in vitro in the presence of basic protein and measles antigens. Quantitative studies with a liquid scintillation technique after incorporation of tritiated thymidine showed impaired lymphocyte transformation with PHA in 9 out of 26 MS patients. There was a correlation between duration of the disease and transformation of lymphocytes from MS patients.",

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AU - Offner, H.

AU - Ammitzboll, T.

AU - Clausen, J.

AU - Fog, T.

AU - Hyllested, K.

AU - Einstein, E.

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IMMUNE RESPONSE OF LYMPHOCYTES FROM PATIENTS WITH MULTIPLE SCLEROSIS TO PHYTOHEMAGGLUTININ, BASIC PROTEIN OF MYELIN AND MEASLES ANTIGENS

Abstract

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