Immunological Ocular Disease

James T. Rosenbaum, Phoebe Lin

Research output: Chapter in Book/Report/Conference proceedingChapter


Immune-mediated disease occurs in a multitude of locations in and around the eye, including the uveal tract in uveitis, the lacrimal gland in Sjögren syndrome, and the sclera in scleritis. The eye is an immune-privileged organ. This chapter reviews several factors that contribute to the uniqueness of the immune response within the eye. Uveitis is a prototype for immune-mediated diseases that affect vision. The differential diagnosis for uveitis is broad. Clinical immunologists should be aware of the relationship between uveitis and systemic diseases, such as ankylosing spondylitis, sarcoidosis, and juvenile idiopathic arthritis. Clinical immunologists often direct systemic immunosuppression in the treatment of uveitis. Scleritis is another vision-threatening, immune-mediated disease that affects the eye; is often associated with a systemic, immune-mediated disease; and often requires systemic immunosuppression. This chapter also addresses keratitis, corneal transplantation, cancer-associated retinopathy, and age-related macular degeneration, since each of these entities is the result of an immune or inflammatory response.

Original languageEnglish (US)
Title of host publicationClinical Immunology
Subtitle of host publicationPrinciples and Practice
ISBN (Electronic)9780702068966
ISBN (Print)9780702070396
StatePublished - Jan 1 2019


  • biologics
  • cystoid macular edema
  • ocular immune privilege
  • peripheral ulcerative keratitis
  • retinal vasculitis
  • Tumor necrosis factor (TNF)-α inhibitors
  • Uveitis scleritis

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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