Immunoneutralization of oxytocin attenuates stress-induced corticotropin secretion in the rat

Daniel M. Gibbs

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Recent studies have demonstrated that oxytocin (OT) is released during certain stresses and that OT can potentiate the activity of CRF in vitro. To better define the role of OT during stress, the effect of injections of anti-OT antiserum on stress-induced corticotropin (ACTH) secretion was studied in vivo. A dose of antiserum which completely neutralized the increase in plasma OT levels during tail-hang stress caused a 59% decrease in plasma ACTH concentrations (P < 0.005). The data support a physiologic role for OT in the regulation of ACTH secretion.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalRegulatory Peptides
Issue number4
StatePublished - Nov 28 1985
Externally publishedYes


  • ACTH
  • oxytocin
  • stress

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience


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