@article{3356d4a74f5946ae81eedd7533f2ef46,
title = "Immunopathology and electron microscopy of Acanthamoeba keratitis",
abstract = "In order to evaluate the local cellular immune response to Acanthamoeba infection we performed immunohistochemical examinations of the corneal buttons of two patients with Acanthamoeba keratitis. We found that the corneal stroma was infiltrated with polymorphonuclear leukocytes and HLA-DR positive macrophages that appeared to be stromal keratocytes by light microscopy. Despite the presence of chronic inflammation in both patients, no stromal lymphocytes were seen in one patient and a sparse lymphocytic infiltrate was seen in the other patient. Electron microscopy confirmed the presence of macrophages, neutrophils, and Acanthamoeba organisms in these two patients.",
author = "W. Mathers and G. Stevens and M. Rodrigues and Chan, {C. C.} and J. Gold and Visvesvara, {G. S.} and Lemp, {M. A.} and Zimmerman, {L. E.}",
note = "Funding Information: Accepted for publication Jan. 27, 1987. From the Cornea Service, Center For Sight, Georgetown University (Drs. Mathers, Stevens, Gold, and Lemp); Laboratory of Pathology (Dr. Rodrigues) and Laboratory of Immunology (Drs. Stevens and Chan), National Eye Institute; Protozoal Diseases Branch, Center for Infectious Diseases, Centers for Disease Control (Dr. Visvesvara); and Department of Pathology, Georgetown University and Department of Ophthalmic Pathology, Armed Forces Institute of Pathology (Dr. Zimmerman). This study was supported by an unrestricted grant from Research to Prevent Blindness, Inc. (Dr. Lemp). This study was presented in part at the annual meeting of the Ocular Microbiology and Immunology Group, Nov. 8, 1986, in New Orleans, Louisiana. Reprint requests to William Mathers, M.D., University of Arizona, Department of Ophthalmology, 1501 N. Campbell St., Tucson, AZ 85724.",
year = "1987",
doi = "10.1016/s0002-9394(14)74321-1",
language = "English (US)",
volume = "103",
pages = "626--635",
journal = "American journal of ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "5 III",
}