Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Tiffany C. Blair; Minsha Manoharan; Stephanie D. Rawlings-Rhea; Ian Tagge; Steven G. Kohama; Julie Hollister-Smith; Betsy Ferguson; Randall L. Woltjer; Meredith C. Frederick; James Pollaro; William D. Rooney; Larry S. Sherman; Dennis N. Bourdette; Scott W. Wong

doi:10.1016/j.jneuroim.2015.11.026

Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Tiffany C. Blair, Minsha Manoharan, Stephanie D. Rawlings-Rhea, Ian Tagge, Steven G. Kohama, Julie Hollister-Smith, Betsy Ferguson, Randall L. Woltjer, Meredith C. Frederick, James Pollaro, William D. Rooney, Larry S. Sherman, Dennis N. Bourdette, Scott W. Wong

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T₂-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	291
DOIs	https://doi.org/10.1016/j.jneuroim.2015.11.026
State	Published - Feb 15 2016

Keywords

Demyelination
Inflammatory
Interleukin 17 (IL-17)
Intrathecal IgG
Magnetic resonance imaging (MRI)
Th1
Th17

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Blair, T. C., Manoharan, M., Rawlings-Rhea, S. D., Tagge, I., Kohama, S. G., Hollister-Smith, J., Ferguson, B., Woltjer, R. L., Frederick, M. C., Pollaro, J., Rooney, W. D., Sherman, L. S., Bourdette, D. N., & Wong, S. W. (2016). Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis. Journal of Neuroimmunology, 291, 1-10. https://doi.org/10.1016/j.jneuroim.2015.11.026

Blair, TC, Manoharan, M, Rawlings-Rhea, SD, Tagge, I, Kohama, SG, Hollister-Smith, J, Ferguson, B, Woltjer, RL, Frederick, MC, Pollaro, J, Rooney, WD , Sherman, LS, Bourdette, DN & Wong, SW 2016, 'Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis', Journal of Neuroimmunology, vol. 291, pp. 1-10. https://doi.org/10.1016/j.jneuroim.2015.11.026

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title = "Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis",

abstract = "Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.",

keywords = "Demyelination, Inflammatory, Interleukin 17 (IL-17), Intrathecal IgG, Magnetic resonance imaging (MRI), Th1, Th17",

author = "Blair, {Tiffany C.} and Minsha Manoharan and Rawlings-Rhea, {Stephanie D.} and Ian Tagge and Kohama, {Steven G.} and Julie Hollister-Smith and Betsy Ferguson and Woltjer, {Randall L.} and Frederick, {Meredith C.} and James Pollaro and Rooney, {William D.} and Sherman, {Larry S.} and Bourdette, {Dennis N.} and Wong, {Scott W.}",

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doi = "10.1016/j.jneuroim.2015.11.026",

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AU - Blair, Tiffany C.

AU - Manoharan, Minsha

AU - Rawlings-Rhea, Stephanie D.

AU - Tagge, Ian

AU - Kohama, Steven G.

AU - Hollister-Smith, Julie

AU - Ferguson, Betsy

AU - Woltjer, Randall L.

AU - Frederick, Meredith C.

AU - Pollaro, James

AU - Rooney, William D.

AU - Sherman, Larry S.

AU - Bourdette, Dennis N.

AU - Wong, Scott W.

PY - 2016/2/15

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N2 - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

AB - Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

KW - Demyelination

KW - Inflammatory

KW - Interleukin 17 (IL-17)

KW - Intrathecal IgG

KW - Magnetic resonance imaging (MRI)

KW - Th1

KW - Th17

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JF - Journal of Neuroimmunology

ER -

Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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