TY - JOUR
T1 - Immunophenotypic variations of Burkitt lymphoma
AU - Kelemen, Katalin
AU - Braziel, Rita M.
AU - Gatter, Ken
AU - Bakke, Tony C.
AU - Olson, Susan
AU - Fan, Guang
PY - 2010/7
Y1 - 2010/7
N2 - Burkitt lymphoma (BL) exhibits a characteristic immunophenotype that is positive for pan-B-cell antigens and CD10 and expresses clonal surface immunoglobulins (SIgs). We evaluated 35 BLs and identified atypical immunophenotypes in 4 including SIg light chain negativity in 4, negativity for B-cell antigens in 2, lack of CD10 in 1, and CD4 expression in 1. All 4 cases showed morphologic features characteristic of BL, and all were confirmed by cytogenetic analysis. The 4 BL cases included 1 girl, 2 men with HIV/AIDS, and a third man with a history of heart transplantation. Two patients died shortly after diagnosis; the other 2 completed hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone with highly active antiretroviral therapy and achieved complete remission. Our study indicates that an unusual immunophenotype is not uncommon in BL. If the immunophenotype is interpreted in isolation, the diagnosis could be missed. Recognizing the variability of immunophenotype is essential for establishing an accurate diagnosis of BL.
AB - Burkitt lymphoma (BL) exhibits a characteristic immunophenotype that is positive for pan-B-cell antigens and CD10 and expresses clonal surface immunoglobulins (SIgs). We evaluated 35 BLs and identified atypical immunophenotypes in 4 including SIg light chain negativity in 4, negativity for B-cell antigens in 2, lack of CD10 in 1, and CD4 expression in 1. All 4 cases showed morphologic features characteristic of BL, and all were confirmed by cytogenetic analysis. The 4 BL cases included 1 girl, 2 men with HIV/AIDS, and a third man with a history of heart transplantation. Two patients died shortly after diagnosis; the other 2 completed hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone with highly active antiretroviral therapy and achieved complete remission. Our study indicates that an unusual immunophenotype is not uncommon in BL. If the immunophenotype is interpreted in isolation, the diagnosis could be missed. Recognizing the variability of immunophenotype is essential for establishing an accurate diagnosis of BL.
KW - Aberrant immunophenotype
KW - Burkitt lymphoma
KW - Flow cytometry
UR - http://www.scopus.com/inward/record.url?scp=77954510808&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954510808&partnerID=8YFLogxK
U2 - 10.1309/AJCP93LJPTRQPDKR
DO - 10.1309/AJCP93LJPTRQPDKR
M3 - Article
C2 - 20551277
AN - SCOPUS:77954510808
SN - 0002-9173
VL - 134
SP - 127
EP - 138
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 1
ER -