Immunosuppressive activity of serum during the development of Experimental Allergic Encephalomyelitis

Arthur A. Vandenbark; Bruce L. Gibbins; David J. Hinrichs

doi:10.1016/0008-8749(74)90001-X

Immunosuppressive activity of serum during the development of Experimental Allergic Encephalomyelitis

Arthur A. Vandenbark, Bruce L. Gibbins, David J. Hinrichs

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The development of Experimental Allergic Encephalomyelitis (EAE), an auto-immune disease directed against the central nervous system, causes a marked increase of serum contained alpha globulins. Serum with elevated alpha globulins decreases the uptake of ³H-thymidine into mitogen stimulated normal or immune lymphocytes. The increased alpha globulin levels and immunosuppressive activity parallel the development of clinical signs.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Cellular Immunology
Volume	11
Issue number	1-3
DOIs	https://doi.org/10.1016/0008-8749(74)90001-X
State	Published - Mar 30 1974
Externally published	Yes

ASJC Scopus subject areas

Immunology

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10.1016/0008-8749(74)90001-X

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title = "Immunosuppressive activity of serum during the development of Experimental Allergic Encephalomyelitis",

abstract = "The development of Experimental Allergic Encephalomyelitis (EAE), an auto-immune disease directed against the central nervous system, causes a marked increase of serum contained alpha globulins. Serum with elevated alpha globulins decreases the uptake of 3H-thymidine into mitogen stimulated normal or immune lymphocytes. The increased alpha globulin levels and immunosuppressive activity parallel the development of clinical signs.",

author = "Vandenbark, {Arthur A.} and Gibbins, {Bruce L.} and Hinrichs, {David J.}",

year = "1974",

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AU - Vandenbark, Arthur A.

AU - Gibbins, Bruce L.

AU - Hinrichs, David J.

PY - 1974/3/30

Y1 - 1974/3/30

N2 - The development of Experimental Allergic Encephalomyelitis (EAE), an auto-immune disease directed against the central nervous system, causes a marked increase of serum contained alpha globulins. Serum with elevated alpha globulins decreases the uptake of 3H-thymidine into mitogen stimulated normal or immune lymphocytes. The increased alpha globulin levels and immunosuppressive activity parallel the development of clinical signs.

AB - The development of Experimental Allergic Encephalomyelitis (EAE), an auto-immune disease directed against the central nervous system, causes a marked increase of serum contained alpha globulins. Serum with elevated alpha globulins decreases the uptake of 3H-thymidine into mitogen stimulated normal or immune lymphocytes. The increased alpha globulin levels and immunosuppressive activity parallel the development of clinical signs.

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ER -

Immunosuppressive activity of serum during the development of Experimental Allergic Encephalomyelitis

Abstract

ASJC Scopus subject areas

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