Impact of mindfulness-based stress reduction for people with multiple sclerosis at 8 weeks and 12 months: A randomized clinical trial

Angela Senders, Douglas Hanes, Dennis Bourdette, Kimberly Carson, Lynn M. Marshall, Lynne Shinto

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background: Mindfulness training is often used as a therapeutic intervention to manage stress and enhance emotional well-being, yet trials for multiple sclerosis (MS) are limited and few have used an active control. Objective: Assess the feasibility of mindfulness-based stress reduction (MBSR) for people with MS and evaluate the efficacy of MBSR compared to an education control. Methods: We conducted a single-blind, randomized trial of MBSR versus education control among 62 adults with MS. Primary outcomes were measures of feasibility. Secondary outcomes included perceived stress, anxiety, depression, fatigue, pain, resilience, and the Paced Auditory Serial Addition Test, assessed at baseline, 8 weeks, and 12 months. Mean scores for secondary outcome measures were compared between groups at each time point and within groups across time by analyses of covariance or paired t-tests, respectively. Results: Successful recruitment and retention demonstrated feasibility. Improvements in several secondary outcomes were observed among both MBSR and control groups. However, differences between the groups were not statistically significant at either 8 weeks or 12 months. Conclusion: Emotional well-being improved with both MBSR and education. Spontaneous improvement cannot be ruled out as an explanation for findings and additional studies that evaluate the impact of mindfulness training to improve emotional health are warranted.

Original languageEnglish (US)
Pages (from-to)1178-1188
Number of pages11
JournalMultiple Sclerosis Journal
Volume25
Issue number8
DOIs
StatePublished - Jul 1 2019

Keywords

  • Multiple sclerosis
  • anxiety
  • mindfulness
  • psychological stress
  • quality of life
  • resilience

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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