Impact of TP53 mutations in Triple Negative Breast Cancer

Zahi I. Mitri; Nour Abuhadra; Shaun M. Goodyear; Evthokia A. Hobbs; Andy Kaempf; Alastair M. Thompson; Stacy L. Moulder

doi:10.1038/s41698-022-00303-6

Impact of TP53 mutations in Triple Negative Breast Cancer

Zahi I. Mitri, Nour Abuhadra, Shaun M. Goodyear, Evthokia A. Hobbs, Andy Kaempf, Alastair M. Thompson, Stacy L. Moulder

Knight Cancer Institute

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.

Original language	English (US)
Article number	64
Journal	npj Precision Oncology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/s41698-022-00303-6
State	Published - Dec 2022

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.",

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AU - Abuhadra, Nour

AU - Goodyear, Shaun M.

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AU - Kaempf, Andy

AU - Thompson, Alastair M.

AU - Moulder, Stacy L.

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AB - Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.

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Impact of TP53 mutations in Triple Negative Breast Cancer

Abstract

ASJC Scopus subject areas

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