@article{03d2fec3da1d488fa23c18350ed09d32,
title = "Impact of TP53 mutations in Triple Negative Breast Cancer",
abstract = "Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.",
author = "Mitri, {Zahi I.} and Nour Abuhadra and Goodyear, {Shaun M.} and Hobbs, {Evthokia A.} and Andy Kaempf and Thompson, {Alastair M.} and Moulder, {Stacy L.}",
note = "Funding Information: The data collection and analysis of this work was supported by an American Society for Clinical Oncology (ASCO) Conquer Cancer Foundation Young Investigator Award to Z.I.M. Thank you to Dr. Fraser Symmans for TP53 sequencing and pathological outcomes review of biospecimens, and Dr. Olivier Lichtarge for providing EAS analysis. We whole-heartedly express our thanks to Dr. Kenneth Hess, PhD for his valuable biostatistical contributions to this project before his passing. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41698-022-00303-6",
language = "English (US)",
volume = "6",
journal = "npj Precision Oncology",
issn = "2397-768X",
publisher = "Springer Nature",
number = "1",
}