Improved dental adhesive formulations based on reactive nanogel additives

R. R. Morães, J. W. Garcia, N. D. Wilson, S. H. Lewis, M. D. Barros, B. Yang, C. S. Pfeifer, J. W. Stansbury

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Current challenges in adhesive dentistry include over-hydrophilic bonding formulations, which facilitate water percolation through the hybrid layer and result in unreliable bonded interfaces. This study introduces nanogel-modified adhesives as a way to control the material's hydrophobic character without changing the basic monomer formulation (keeping water-chasing capacity and operatory techniques unaltered). Nanogel additives of varied hydrophobicity were synthesized in solution, rendering 10- to 100-nm-sized particles. A model BisGMA/HEMA solvated adhesive was prepared (control), to which reactive nanogels were added. The increase in adhesive viscosity did not impair solvent removal by air-thinning. The degree of conversion in the adhesive was similar between control and nanogel-modified materials, while the bulk dry and, particularly, the wet mechanical properties were significantly improved through nanogel-based network reinforcement and reduced water solubility. As preliminary validation of this approach, short-term micro-tensile bond strengths to acid-etched and primed dentin were significantly enhanced by nanogel inclusion in the adhesive resins.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalJournal of dental research
Issue number2
StatePublished - Feb 2012
Externally publishedYes


  • adhesives
  • materials science(s)
  • nanoparticles
  • polymers
  • restorative dentistry
  • water

ASJC Scopus subject areas

  • Dentistry(all)


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