In search of a hepatic osmoreceptor in man

William M. Bennett, David Hennes, Diane Elliot, George A. Porter

Research output: Contribution to journalArticlepeer-review


In an attempt to demonstrate an effect of a decrease in portal venous osmolarity in promoting an enhanced water diuresis in man, 10 volunteers were given 500 ml loads of .45% NaCl orally and intravenously. Paired observations at 20-minute intervals showed significant increase in free water clearance following oral loads at 80 minutes only (p<.05). Urine volume between the 2 routes of administration showed no significant difference. Doubling the size of the load or changing the order of administration did not enhance the response to oral loading. No conclusive evidence for existence of a hepatic osmoreceptor in man was obtained.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalThe American Journal of Digestive Diseases
Issue number2
StatePublished - Feb 1974

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'In search of a hepatic osmoreceptor in man'. Together they form a unique fingerprint.

Cite this