In vivo imaging and low-coherence interferometry of organ of Corti vibration

Fangyi Chen; Niloy Choudhury; Jiefu Zheng; Scott Matthews; Alfred L. Nutall; Steven L. Jacques

doi:10.1117/1.2717134

In vivo imaging and low-coherence interferometry of organ of Corti vibration

Fangyi Chen
, Niloy Choudhury
, Jiefu Zheng
, Scott Matthews
, Alfred L. Nutall
, Steven L. Jacques

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

An optical coherence tomography (OCT) system is built to acquire in vivo both images and vibration measurements of the organ of Corti of the guinea pig. The organ of Corti is viewed through a ∼ 300-μ m-diam hole in the bony wall of the cochlea at the scala tympani of the first cochlear turn. In imaging mode, the image is acquired as reflectance R(x,z). In vibration mode, the basilar membrane (BM) or reticular lamina (RL) are selected by the investigator interactively from the R(x,z) image. Under software control, the system moves the scanning mirrors to bring the sensing volume of the measurement to the desired membrane location. In vivo images of the organ of Corti are presented, indicating reflectance signals from the BM, RL, tectorial membrane, and Reissner's membrane. The tunnel of Corti and the inner sulcus are also visible in the images. Vibrations of ± 2 and ± 22 nm are recorded in the BM in response to low and high sound levels at 14 kHz above a noise floor of 0.2 nm.

Original language	English (US)
Article number	021006
Journal	Journal of biomedical optics
Volume	12
Issue number	2
DOIs	https://doi.org/10.1117/1.2717134
State	Published - Mar 1 2007

Funding

This work was supported by the National Institutes of Health, primarily NIDCD RO1-DC006273 with partial support from NIDCD R01-DC00141 and NIDCD P30-DC005983.

Funders

Funder number

Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health

National Institute on Deafness and Other Communication Disorders R01DC012546 Xue Zhong Liu National Institute on Deafness and Other Communication Disorders R01DC012115 Xue Zhong Liu National Institute on Deafness and Other Communication Disorders R01DC014427 Ulrich Müller Peter G Barr-Gillespie National Institute on Deafnessand Other Communication Disorders R01DC005965 Ulrich Müller National Institute on Deafness and Other Communication Disorders

RO1-DC006273, R01-DC00141, P30DC005983

Keywords

Cochlea
Interferometry
Optical coherence tomography
Vibration

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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10.1117/1.2717134

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title = "In vivo imaging and low-coherence interferometry of organ of Corti vibration",

abstract = "An optical coherence tomography (OCT) system is built to acquire in vivo both images and vibration measurements of the organ of Corti of the guinea pig. The organ of Corti is viewed through a ∼ 300-μ m-diam hole in the bony wall of the cochlea at the scala tympani of the first cochlear turn. In imaging mode, the image is acquired as reflectance R(x,z). In vibration mode, the basilar membrane (BM) or reticular lamina (RL) are selected by the investigator interactively from the R(x,z) image. Under software control, the system moves the scanning mirrors to bring the sensing volume of the measurement to the desired membrane location. In vivo images of the organ of Corti are presented, indicating reflectance signals from the BM, RL, tectorial membrane, and Reissner's membrane. The tunnel of Corti and the inner sulcus are also visible in the images. Vibrations of ± 2 and ± 22 nm are recorded in the BM in response to low and high sound levels at 14 kHz above a noise floor of 0.2 nm.",

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author = "Fangyi Chen and Niloy Choudhury and Jiefu Zheng and Scott Matthews and Nutall, \{Alfred L.\} and Jacques, \{Steven L.\}",

note = "Funding Information: This work was supported by the National Institutes of Health, primarily NIDCD RO1-DC006273 with partial support from NIDCD R01-DC00141 and NIDCD P30-DC005983.",

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AU - Jacques, Steven L.

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N2 - An optical coherence tomography (OCT) system is built to acquire in vivo both images and vibration measurements of the organ of Corti of the guinea pig. The organ of Corti is viewed through a ∼ 300-μ m-diam hole in the bony wall of the cochlea at the scala tympani of the first cochlear turn. In imaging mode, the image is acquired as reflectance R(x,z). In vibration mode, the basilar membrane (BM) or reticular lamina (RL) are selected by the investigator interactively from the R(x,z) image. Under software control, the system moves the scanning mirrors to bring the sensing volume of the measurement to the desired membrane location. In vivo images of the organ of Corti are presented, indicating reflectance signals from the BM, RL, tectorial membrane, and Reissner's membrane. The tunnel of Corti and the inner sulcus are also visible in the images. Vibrations of ± 2 and ± 22 nm are recorded in the BM in response to low and high sound levels at 14 kHz above a noise floor of 0.2 nm.

AB - An optical coherence tomography (OCT) system is built to acquire in vivo both images and vibration measurements of the organ of Corti of the guinea pig. The organ of Corti is viewed through a ∼ 300-μ m-diam hole in the bony wall of the cochlea at the scala tympani of the first cochlear turn. In imaging mode, the image is acquired as reflectance R(x,z). In vibration mode, the basilar membrane (BM) or reticular lamina (RL) are selected by the investigator interactively from the R(x,z) image. Under software control, the system moves the scanning mirrors to bring the sensing volume of the measurement to the desired membrane location. In vivo images of the organ of Corti are presented, indicating reflectance signals from the BM, RL, tectorial membrane, and Reissner's membrane. The tunnel of Corti and the inner sulcus are also visible in the images. Vibrations of ± 2 and ± 22 nm are recorded in the BM in response to low and high sound levels at 14 kHz above a noise floor of 0.2 nm.

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KW - Vibration

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In vivo imaging and low-coherence interferometry of organ of Corti vibration

Abstract

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Keywords

ASJC Scopus subject areas

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