In vivo imaging of the immune response in the eye

Doran B. Spencer; Ellen J. Lee; Tatsushi Kawaguchi; James T. Rosenbaum

doi:10.1007/s00281-008-0107-6

In vivo imaging of the immune response in the eye

Doran B. Spencer, Ellen J. Lee, Tatsushi Kawaguchi, James T. Rosenbaum

Ophthalmology

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The immune system is governed by dynamic events involving in part direct intercellular interactions between an immune cell and other cells or the cell's environment. Owing to its unique optical characteristics, the eye offers remarkable opportunities for the analysis of the immune system by intravital microscopy. In this review, we present a brief overview of the current state of knowledge of leukocyte trafficking in each of three anatomically distinct and medically important regions of the eye (cornea, iris, retina) as determined by the application of intravital microscopy to animal models of disease. Additionally, we discuss the use of ocular imaging in patients and volunteers. Finally, we examine the future prospects for this field in terms of its potential for impacting our understanding of fundamental immunological phenomena.

Original language	English (US)
Pages (from-to)	179-190
Number of pages	12
Journal	Seminars in Immunopathology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1007/s00281-008-0107-6
State	Published - Apr 2008

Keywords

Antigen-presenting cells
Cell migration
Intravital microscopy
Mice
T cells
Uveitis

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1007/s00281-008-0107-6

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title = "In vivo imaging of the immune response in the eye",

abstract = "The immune system is governed by dynamic events involving in part direct intercellular interactions between an immune cell and other cells or the cell's environment. Owing to its unique optical characteristics, the eye offers remarkable opportunities for the analysis of the immune system by intravital microscopy. In this review, we present a brief overview of the current state of knowledge of leukocyte trafficking in each of three anatomically distinct and medically important regions of the eye (cornea, iris, retina) as determined by the application of intravital microscopy to animal models of disease. Additionally, we discuss the use of ocular imaging in patients and volunteers. Finally, we examine the future prospects for this field in terms of its potential for impacting our understanding of fundamental immunological phenomena.",

keywords = "Antigen-presenting cells, Cell migration, Intravital microscopy, Mice, T cells, Uveitis",

author = "Spencer, {Doran B.} and Lee, {Ellen J.} and Tatsushi Kawaguchi and Rosenbaum, {James T.}",

note = "Funding Information: We would like to acknowledge the support of National Institute of Health grants EY015448 (E.J.L), EY006484 and EY013093 (J.T.R., D.B.S, T.K.), as well as Research to Prevent Blindness awards to JTR and the CEI. We are also grateful for support from The Stan and Madelle Rosenfeld Family Trust, the Bauman Foundation, and OHSU Foundation. We would also like to acknowledge the valuable input of Steve Planck and the technical assistance of Mischa Ronick, Shannon Douglas, and Kellen Galster as well as Lyndell Lim for constructive comments on the manuscript.",

year = "2008",

month = apr,

doi = "10.1007/s00281-008-0107-6",

language = "English (US)",

volume = "30",

pages = "179--190",

journal = "Seminars in Immunopathology",

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AU - Spencer, Doran B.

AU - Lee, Ellen J.

AU - Kawaguchi, Tatsushi

AU - Rosenbaum, James T.

N1 - Funding Information: We would like to acknowledge the support of National Institute of Health grants EY015448 (E.J.L), EY006484 and EY013093 (J.T.R., D.B.S, T.K.), as well as Research to Prevent Blindness awards to JTR and the CEI. We are also grateful for support from The Stan and Madelle Rosenfeld Family Trust, the Bauman Foundation, and OHSU Foundation. We would also like to acknowledge the valuable input of Steve Planck and the technical assistance of Mischa Ronick, Shannon Douglas, and Kellen Galster as well as Lyndell Lim for constructive comments on the manuscript.

PY - 2008/4

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N2 - The immune system is governed by dynamic events involving in part direct intercellular interactions between an immune cell and other cells or the cell's environment. Owing to its unique optical characteristics, the eye offers remarkable opportunities for the analysis of the immune system by intravital microscopy. In this review, we present a brief overview of the current state of knowledge of leukocyte trafficking in each of three anatomically distinct and medically important regions of the eye (cornea, iris, retina) as determined by the application of intravital microscopy to animal models of disease. Additionally, we discuss the use of ocular imaging in patients and volunteers. Finally, we examine the future prospects for this field in terms of its potential for impacting our understanding of fundamental immunological phenomena.

AB - The immune system is governed by dynamic events involving in part direct intercellular interactions between an immune cell and other cells or the cell's environment. Owing to its unique optical characteristics, the eye offers remarkable opportunities for the analysis of the immune system by intravital microscopy. In this review, we present a brief overview of the current state of knowledge of leukocyte trafficking in each of three anatomically distinct and medically important regions of the eye (cornea, iris, retina) as determined by the application of intravital microscopy to animal models of disease. Additionally, we discuss the use of ocular imaging in patients and volunteers. Finally, we examine the future prospects for this field in terms of its potential for impacting our understanding of fundamental immunological phenomena.

KW - Antigen-presenting cells

KW - Cell migration

KW - Intravital microscopy

KW - Mice

KW - T cells

KW - Uveitis

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In vivo imaging of the immune response in the eye

Abstract

Keywords

ASJC Scopus subject areas

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