@inproceedings{252eb0411d8f494fa72a10613f03a0a9,
title = "In vivo nerve-specificity of rhodamines and Si-rhodamines",
abstract = "Accidental nerve damage or transection of vital nerve structures remains an unfortunate reality that is often a{\ss}ociated with surgery. Despite the existence of nerve-sparing techniques, the succe{\ss} of such procedures is not only complicated by anatomical variance acro{\ss} patients but is also highly dependent on a surgeon's first-hand experience that is acquired over numerous procedures through trial and error, often with highly variable succe{\ss} rates. Fluorescent small molecules, such as rhodamines and fluoresceins have proven incredibly useful for biological imaging in the life sciences, and they appeared to have potential in illuminating vital nerve structures during surgical procedures. In order to make use of the current clinically relevant imaging systems and to provide surgeons with fluorescent contrast largely free from the interference of hemoglobin and water, it was first nece{\ss}ary to spectrally tune known fluorescent scaffolds towards near infrared (NIR) wavelengths. To determine whether the well-documented Si-substitution strategy could be applied towards developing a NIR fluorophore that retained nerve-specific properties of candidate molecules, an in vivo comparison was made between two compounds previously shown to highlight nervous structures - TMR and Rhodamine B - and their Si-substituted derivatives.",
keywords = "Contrast agent, Fluorescent imaging, Image-guided surgery, Nerve-specific Fluorophores",
author = "Montano, {Antonio R.} and Wang, {Lei G.} and Barth, {Connor W.} and Shams, {Nourhan A.} and Kumarapeli, {K. A.Sashini U.} and Gibbs, {Summer L.}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Molecular-Guided Surgery: Molecules, Devices, and Applications VI 2020 ; Conference date: 01-02-2020 Through 02-02-2020",
year = "2020",
doi = "10.1117/12.2545311",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Sylvain Gioux and Gibbs, {Summer L.} and Pogue, {Brian W.}",
booktitle = "Molecular-Guided Surgery",
}