@article{46434e4562044bbdace021db280f2b4a,
title = "Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus",
abstract = "Recent clinical and laboratory observations support a potential role for the platelet FcγRIIA receptor (FcR) in collagen-mediated platelet activation associated with arterial thrombosis. Stable age- and sex-independent variation in receptor expression exists. Flow cytometry showed that 100 diabetes patients had increased mean platelet FcR expression levels compared with 201 non-diabetes patients (P < 0.001). Aggregation studies following FcR cross-linking supported a receptor role in increased activation of diabetes platelets after collagen stimulation (P = 0.018). Immunoprecipitation of collagen-stimulated and FcR-crosslinked platelets demonstrated enhanced levels of tyrosine-phosphorylated Syk in diabetic platelets. Increased platelet FcR-mediated sensitivity to collagen may contribute to cardiovascular morbidity and mortality in diabetes.",
keywords = "Blood platelets, Cardiovascular disease, Collagen, Diabetes mellitus, Fc, Receptors",
author = "Calverley, \{David C.\} and Hacker, \{Michele R.\} and Loda, \{Kimberly A.\} and Elizabeth Brass and Buchanan, \{Thomas A.\} and Tsao-Wei, \{Denice D.\} and Susan Groshen",
year = "2003",
month = apr,
day = "1",
doi = "10.1046/j.1365-2141.2003.04233.x",
language = "English (US)",
volume = "121",
pages = "139--142",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley and Sons Inc.",
number = "1",
}