Increasing patient participation in oncology clinical trials

Jie Chen, Ying Lu, Shivaani Kummar

Research output: Contribution to journalReview articlepeer-review


Aim: Timely recruitment of eligible participants is essential for the success of clinical trials, with insufficient accrual being the leading cause for premature termination of both oncology and non-oncology trials. Methods: In this paper we further elaborate on the challenges for patient participation in oncology trials from physician, patient, healthcare system, and some trial-related perspectives. Results: We present strategies such as use of digital healthcare technologies, real-world data and real-world evidence, decentralized clinical trials, pragmatic trial designs, and supportive services to increase patient participation. Conclusions: Multifaceted measures are necessary to increase patient participation, especially for those who are under-represented in cancer trials.

Original languageEnglish (US)
Pages (from-to)2219-2226
Number of pages8
JournalCancer medicine
Issue number3
StatePublished - Feb 2023


  • cancer trials
  • clinical trials
  • patient accrual
  • pragmatic clinical trials

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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