Abstract
Long-term dormancy of murine B-cell lymphomas can be experimentally induced by immunizing the host with the idiotype expressed on the tumor. Interaction of the cells with anti-idiotype antibodies is sufficient to induce and maintain the dormant state. The growth of lymphoma cells interacting with anti-idiotype antibodies is arrested and they undergo dramatic changes in their morphology, cell-cycle status and oncogene expression. Regrowth of a tumor after long-term dormancy results from the emergence of a tumor cell variant that no longer responds to the antibodies with growth inhibition. These data demonstrate the feasibility of reversing a malignant phenotype of cells by specific growth arrest signals and suggest new approaches for therapeutic intervention in cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 740-744 |
| Number of pages | 5 |
| Journal | Current opinion in immunology |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1993 |
| Externally published | Yes |
Funding
We gratefully acknowledge the support of the National Health Grant No. ROI-CA58321, the Tobacco Research Society of Research Associates of the Lautenberg Center, II Foundation and the Wakefern/ShopRite Endowment.
| Funders | Funder number |
|---|---|
| Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health | |
| National Institute of Health-National Cancer Institute | R01CA058321 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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