Influence of pentobarbital on synaptic plasma membrane protein synthesis

Robert J. Hitzemann, Horace H. Loh

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The effects of acute and chronic pentobarbital treatment on the incorporation of 3H-lysine into rat brain synaptic plasma membranes (SPM) were examined by means of SDS polyacrylamide gel electrophoresis. The data suggest the major effects of both drug treatments are found in a unique population of SPM derived from a light population of nerve ending particles (NEP). These light NEP preferentially accumulate labelled GABA, suggesting this fraction is enriched in GABA containing nerve terminals.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalLife Sciences
Issue number1
StatePublished - Jan 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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