Innate Immune signals in autoimmune and autoinflammatory uveitis

James T. Rosenbaum; Hyun Woong Kim

doi:10.3109/08830185.2012.750132

Innate Immune signals in autoimmune and autoinflammatory uveitis

James T. Rosenbaum
, Hyun Woong Kim

Ophthalmology

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Although traditionally the adaptive immune system has been viewed as the essential contributor to autoimmune diseases, the evidence implicating the innate immune system has grown considerably in recent years. Several multisystem inflammatory diseases affect the uvea and occur as a result of a mutation in a gene coding for a component of the innate immune system. Diseases associated with uveitis such as ankylosing spondylitis, sarcoidosis, Behcet's disease and inflammatory bowel disease can best be conceptually understood by hypotheses that consider microbial infection and innate immunity as contributing factors.

Original language	English (US)
Pages (from-to)	68-75
Number of pages	8
Journal	International reviews of immunology
Volume	32
Issue number	1
DOIs	https://doi.org/10.3109/08830185.2012.750132
State	Published - Feb 2013

Funding

This research was supported in part by the National Institutes of Health (NIH) grant EY 021733 and by unrestricted funds from Research to Prevent Blindness, the Inje Research and Scholarship Foundation (2011), the Stan and Madelle Rosenfeld Family Trust, and the William and Mary Bauman Foundation.

Funders	Funder number
Inje Research and Scholarship Foundation
Stan and Madelle Rosenfeld Family Trust
William and Mary Bauman Foundation
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
National Eye Institute and Casey Eye Institute	R01EY021733
Research to Prevent Blindness

Keywords

Ankylosing spondylitis
Behcet's disease
Inflammatory bowel disease
NOD2
Sarcoidosis
TLR

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3109/08830185.2012.750132

Cite this

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title = "Innate Immune signals in autoimmune and autoinflammatory uveitis",

abstract = "Although traditionally the adaptive immune system has been viewed as the essential contributor to autoimmune diseases, the evidence implicating the innate immune system has grown considerably in recent years. Several multisystem inflammatory diseases affect the uvea and occur as a result of a mutation in a gene coding for a component of the innate immune system. Diseases associated with uveitis such as ankylosing spondylitis, sarcoidosis, Behcet's disease and inflammatory bowel disease can best be conceptually understood by hypotheses that consider microbial infection and innate immunity as contributing factors.",

keywords = "Ankylosing spondylitis, Behcet's disease, Inflammatory bowel disease, NOD2, Sarcoidosis, TLR",

author = "Rosenbaum, \{James T.\} and Kim, \{Hyun Woong\}",

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N2 - Although traditionally the adaptive immune system has been viewed as the essential contributor to autoimmune diseases, the evidence implicating the innate immune system has grown considerably in recent years. Several multisystem inflammatory diseases affect the uvea and occur as a result of a mutation in a gene coding for a component of the innate immune system. Diseases associated with uveitis such as ankylosing spondylitis, sarcoidosis, Behcet's disease and inflammatory bowel disease can best be conceptually understood by hypotheses that consider microbial infection and innate immunity as contributing factors.

AB - Although traditionally the adaptive immune system has been viewed as the essential contributor to autoimmune diseases, the evidence implicating the innate immune system has grown considerably in recent years. Several multisystem inflammatory diseases affect the uvea and occur as a result of a mutation in a gene coding for a component of the innate immune system. Diseases associated with uveitis such as ankylosing spondylitis, sarcoidosis, Behcet's disease and inflammatory bowel disease can best be conceptually understood by hypotheses that consider microbial infection and innate immunity as contributing factors.

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KW - Behcet's disease

KW - Inflammatory bowel disease

KW - NOD2

KW - Sarcoidosis

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Innate Immune signals in autoimmune and autoinflammatory uveitis

Abstract

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Keywords

ASJC Scopus subject areas

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