TY - JOUR
T1 - Insights into the pathogenesis of Sweet's syndrome
AU - Heath, Michael S.
AU - Ortega-Loayza, Alex G.
N1 - Publisher Copyright:
Copyright © 2019 Heath and Ortega-Loayza.
PY - 2019
Y1 - 2019
N2 - Sweet's syndrome, also known as Acute Febrile Neutrophilic Dermatosis, is a rare inflammatory condition. It is considered to be the prototype disease of neutrophilic dermatoses, and presents with acute onset dermal neutrophilic lesions, leukocytosis, and pyrexia. Several variants have been described both clinically and histopathologically. Classifications include classic Sweet's syndrome, malignancy associated, and drug induced. The cellular and molecular mechanisms involved in Sweet's syndrome have been difficult to elucidate due to the large variety of conditions leading to a common clinical presentation. The exact pathogenesis of Sweet's syndrome is unclear; however, new discoveries have shed light on the role of inflammatory signaling, disease induction, and relationship with malignancy. These findings include an improved understanding of inflammasome activation, malignant transformation into dermal infiltrating neutrophils, and genetic contributions. Continued investigations into effective treatments and targeted therapy will benefit patients and improve our molecular understanding of inflammatory diseases, including Sweet's syndrome.
AB - Sweet's syndrome, also known as Acute Febrile Neutrophilic Dermatosis, is a rare inflammatory condition. It is considered to be the prototype disease of neutrophilic dermatoses, and presents with acute onset dermal neutrophilic lesions, leukocytosis, and pyrexia. Several variants have been described both clinically and histopathologically. Classifications include classic Sweet's syndrome, malignancy associated, and drug induced. The cellular and molecular mechanisms involved in Sweet's syndrome have been difficult to elucidate due to the large variety of conditions leading to a common clinical presentation. The exact pathogenesis of Sweet's syndrome is unclear; however, new discoveries have shed light on the role of inflammatory signaling, disease induction, and relationship with malignancy. These findings include an improved understanding of inflammasome activation, malignant transformation into dermal infiltrating neutrophils, and genetic contributions. Continued investigations into effective treatments and targeted therapy will benefit patients and improve our molecular understanding of inflammatory diseases, including Sweet's syndrome.
KW - Acute febrile neutrophilic dermatosis
KW - Autoinflammation
KW - Clonality
KW - Drug induced
KW - Hematology
KW - Malignancy
KW - Neutrophilic dermatoses
UR - http://www.scopus.com/inward/record.url?scp=85063994998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063994998&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2019.00414
DO - 10.3389/fimmu.2019.00414
M3 - Review article
C2 - 30930894
AN - SCOPUS:85063994998
SN - 1664-3224
VL - 10
JO - Frontiers in immunology
JF - Frontiers in immunology
IS - MAR
M1 - 414
ER -