Abstract
The function of insulin-like growth factors I and II (IGF-I and IGF-II) in embryogenesis is unknown. To investigate the ontogeny of IGF gene expression during mammalian development we used a highly sensitive and specific solutionhybridization assay to determine the steady state levels of IGF mRNAs during midgestation in the rat. IGF-I mRNA can be detected as early as day 11 of embryonic development and rises 8.6-fold over the ensuing 48 h. By contrast IGF-II mRNA is relatively constant over days 11-14 of gestation. These observations suggest that both IGFs may play important roles in early fetal development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2141-2144 |
| Number of pages | 4 |
| Journal | Endocrinology |
| Volume | 121 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 1987 |
| Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology