Insulin-like growth factors and cancer

Derek LeRoith; Renato Baserga; Lee Helman; Charles T. Roberts

doi:10.7326/0003-4819-122-1-199501010-00009

Insulin-like growth factors and cancer

Derek LeRoith, Renato Baserga, Lee Helman, Charles T. Roberts

Research output: Contribution to journal › Article › peer-review

303 Scopus citations

Abstract

The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.

Original language	English (US)
Pages (from-to)	54-59
Number of pages	6
Journal	Annals of internal medicine
Volume	122
Issue number	1
DOIs	https://doi.org/10.7326/0003-4819-122-1-199501010-00009
State	Published - Jan 1 1995
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine

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10.7326/0003-4819-122-1-199501010-00009

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title = "Insulin-like growth factors and cancer",

abstract = "The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.",

author = "Derek LeRoith and Renato Baserga and Lee Helman and Roberts, {Charles T.}",

note = "Funding Information: This work was supported by the Foundation for Research in Tumour Diagnostics and Prevention (STIFTUP, CH-9001 St Gallen) and the Foundation of Eugen and Elisabeth Schellenberg (CH-8501 Frauenfeld). ",

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AU - LeRoith, Derek

AU - Baserga, Renato

AU - Helman, Lee

AU - Roberts, Charles T.

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PY - 1995/1/1

Y1 - 1995/1/1

N2 - The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.

AB - The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.

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Insulin-like growth factors and cancer

Abstract

ASJC Scopus subject areas

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