Insulin-like growth factors I and II in evaluation of growth retardation

Ron G. Rosenfeld; Darrell M. Wilson; Phillip D.K. Lee; Raymond L. Hintz

doi:10.1016/S0022-3476(86)80112-3

Insulin-like growth factors I and II in evaluation of growth retardation

Ron G. Rosenfeld
, Darrell M. Wilson
, Phillip D.K. Lee
, Raymond L. Hintz

Research output: Contribution to journal › Article › peer-review

241 Scopus citations

Abstract

Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.

Original language	English (US)
Pages (from-to)	428-433
Number of pages	6
Journal	The Journal of pediatrics
Volume	109
Issue number	3
DOIs	https://doi.org/10.1016/S0022-3476(86)80112-3
State	Published - Sep 1986
Externally published	Yes

Funding

The somatomedins constitute a family of growth hormone-dependent, insulin-like peptides, which are believed to mediate the anabolic actions of growth hormone.~ To date, two human somatomedins, insulin-like growth factors I and II, have been isolated, purified, and sequenced. 2,3 IGF-I is identical to SM-C 4, and IGF-II has major homology with a rat somatomedin, multiplication-stimulating activity. 5 Plasma concentrations of both peptides are, at least in part, controlled by growth hormone, and both peptides possess anabolic and mitogenic actions. 6 Currently, the diagnosis of GH deficiency requires documentation of the patient's inability to raise serum GH concentrations above some arbitrary level, using a variety Supported in part by Research Grants AM28229 (R.G.R.) and AM 24085 (R.L.H.) from the National Institutes of Health. Dr. Lee is a recipient of a fellowship award from the Juvenile Diabetes Foundation. Dr. Rosenfeld is the recipient of a Research Career Development Award from the National Institutes of Health. Submitted for publication Feb. 24, 1986; accepted April 10, 1986. Reprint requests: Ron G. Rosenfeld, M.D., Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305.

Funders
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health
Juvenile Diabetes Research Foundation International

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(86)80112-3

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@article{33205e380827498494b10de4cf29739c,

title = "Insulin-like growth factors I and II in evaluation of growth retardation",

abstract = "Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32\% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52\% of GH-deficient children, but also in 35\% of normal short children. However, only 4\% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5\% of normal children and 11\% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.",

author = "Rosenfeld, \{Ron G.\} and Wilson, \{Darrell M.\} and Lee, \{Phillip D.K.\} and Hintz, \{Raymond L.\}",

note = "Funding Information: The somatomedins constitute a family of growth hormone-dependent, insulin-like peptides, which are believed to mediate the anabolic actions of growth hormone.\textasciitilde{} To date, two human somatomedins, insulin-like growth factors I and II, have been isolated, purified, and sequenced. 2,3 IGF-I is identical to SM-C 4, and IGF-II has major homology with a rat somatomedin, multiplication-stimulating activity. 5 Plasma concentrations of both peptides are, at least in part, controlled by growth hormone, and both peptides possess anabolic and mitogenic actions. 6 Currently, the diagnosis of GH deficiency requires documentation of the patient's inability to raise serum GH concentrations above some arbitrary level, using a variety Supported in part by Research Grants AM28229 (R.G.R.) and AM 24085 (R.L.H.) from the National Institutes of Health. Dr. Lee is a recipient of a fellowship award from the Juvenile Diabetes Foundation. Dr. Rosenfeld is the recipient of a Research Career Development Award from the National Institutes of Health. Submitted for publication Feb. 24, 1986; accepted April 10, 1986. Reprint requests: Ron G. Rosenfeld, M.D., Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305.",

year = "1986",

month = sep,

doi = "10.1016/S0022-3476(86)80112-3",

language = "English (US)",

volume = "109",

pages = "428--433",

journal = "The Journal of pediatrics",

issn = "0022-3476",

publisher = "Elsevier Inc.",

number = "3",

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T1 - Insulin-like growth factors I and II in evaluation of growth retardation

AU - Rosenfeld, Ron G.

AU - Wilson, Darrell M.

AU - Lee, Phillip D.K.

AU - Hintz, Raymond L.

N1 - Funding Information: The somatomedins constitute a family of growth hormone-dependent, insulin-like peptides, which are believed to mediate the anabolic actions of growth hormone.~ To date, two human somatomedins, insulin-like growth factors I and II, have been isolated, purified, and sequenced. 2,3 IGF-I is identical to SM-C 4, and IGF-II has major homology with a rat somatomedin, multiplication-stimulating activity. 5 Plasma concentrations of both peptides are, at least in part, controlled by growth hormone, and both peptides possess anabolic and mitogenic actions. 6 Currently, the diagnosis of GH deficiency requires documentation of the patient's inability to raise serum GH concentrations above some arbitrary level, using a variety Supported in part by Research Grants AM28229 (R.G.R.) and AM 24085 (R.L.H.) from the National Institutes of Health. Dr. Lee is a recipient of a fellowship award from the Juvenile Diabetes Foundation. Dr. Rosenfeld is the recipient of a Research Career Development Award from the National Institutes of Health. Submitted for publication Feb. 24, 1986; accepted April 10, 1986. Reprint requests: Ron G. Rosenfeld, M.D., Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305.

PY - 1986/9

Y1 - 1986/9

N2 - Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.

AB - Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.

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DO - 10.1016/S0022-3476(86)80112-3

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JO - The Journal of pediatrics

JF - The Journal of pediatrics

IS - 3

ER -

Insulin-like growth factors I and II in evaluation of growth retardation

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