TY - JOUR
T1 - Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states
AU - LeRoith, Derek
AU - Adamo, Martin
AU - Werner, Haim
AU - Roberts, Charles T.
PY - 1991
Y1 - 1991
N2 - Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.
AB - Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.
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U2 - 10.1016/1043-2760(91)90003-6
DO - 10.1016/1043-2760(91)90003-6
M3 - Review article
AN - SCOPUS:0025767211
SN - 1043-2760
VL - 2
SP - 134
EP - 139
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 4
ER -